The kinetics of interactions between fecapentaene-12 and DNA

Fecapentaene-12 (Fp-12) is a potent colon cancer mutagen, which interacts with DNA. In this study, the kinetics of its interactions with DNA is investigated. Various pHs are used. Three first-order rates are observed at each pH. This suggests that interaction between Fp-12 and DNA occurs through thr...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2003, Vol.95 (5), p.526-529
Main Authors: Kassaee, Mohammad Zaman, Bekhradnia, Ahmad Reza
Format: Article
Language:English
Subjects:
colon cancer
DNA
fecapentaene-12
Fp-12
INTESTINES
kinetics
mutagen
MUTAGENS
NEOPLASMS
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Summary:Fecapentaene-12 (Fp-12) is a potent colon cancer mutagen, which interacts with DNA. In this study, the kinetics of its interactions with DNA is investigated. Various pHs are used. Three first-order rates are observed at each pH. This suggests that interaction between Fp-12 and DNA occurs through three different mechanisms.
ISSN:1389-1723
1347-4421
DOI:10.1016/S1389-1723(03)80055-5