The long non‐coding RNA H19 rs217727 polymorphism is associated with PE susceptibility

H19 is an imprinted gene transcribing a long noncoding RNA which was previously reported to be involved in some diseases. However, the association between the H19 polymorphisms and Pre‐eclampsia (PE) susceptibility has remained elusive. This study aimed to evaluate the association between three H19...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2018-07, Vol.119 (7), p.5473-5480
Main Authors: Harati‐Sadegh, Mahdiyeh, Kohan, Leila, Teimoori, Batool, Salimi, Saeedeh
Format: Article
Language:English
Subjects:
Alleles
gene
Gene frequency
Gene polymorphism
Genotypes
H19
Haplotypes
Polymerase chain reaction
Polymorphism
Preeclampsia
Restriction fragment length polymorphism
Ribonucleic acid
Risk
RNA
Single-nucleotide polymorphism
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Summary:H19 is an imprinted gene transcribing a long noncoding RNA which was previously reported to be involved in some diseases. However, the association between the H19 polymorphisms and Pre‐eclampsia (PE) susceptibility has remained elusive. This study aimed to evaluate the association between three H19 haplotype SNPs (rs3741219, rs217727, and rs2107425) and the risk of PE. The present case control study consisted of 193 PE women and 201 controls. The H19 rs3741219 and rs217727 polymorphisms were genotyped with PCR‐RFLP (Polymerase chain reaction‐restriction fragment length polymorphism) and the H19 rs2107425 polymorphism with ARMS‐PCR (Amplification refractory mutation system) methods. The frequency of alleles and genotypes of H19 rs3741219 and rs2107425 polymorphisms did not differ between PE women and controls. The frequency of the H19 rs217727T allele was significantly higher in PE women (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.26708