gem-Diborylalkanes: recent advances in their preparation, transformation and application

Recently, gem-diborylalkanes have attracted much attention as versatile building blocks and fundamental intermediates in organic synthesis, because they enable multiple C-C bond construction and further transformation at C-B bonds. Importantly, gem-diborylalkanes can be utilised as bisnucleophilic p...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018, Vol.16 (7), p.1050-1064
Main Authors: Nallagonda, Rajender, Padala, Kishor, Masarwa, Ahmad
Format: Article
Language:English
Subjects:
Chemical bonds
Construction
Homology
Intermediates
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Summary:Recently, gem-diborylalkanes have attracted much attention as versatile building blocks and fundamental intermediates in organic synthesis, because they enable multiple C-C bond construction and further transformation at C-B bonds. Importantly, gem-diborylalkanes can be utilised as bisnucleophilic partners in a variety of chemo-selective C-C bond-forming reactions. This review describes recent developments in synthesising gem-diborylalkanes in complex molecules along with their chemical transformation. In the first part of the review the different synthetic approaches used to synthesise gem-diborylalkanes are described. In the second part, an overview of the chemoselective transformation of gem-diborylalkanes into various functionalized materials is discussed along with one-carbon homologation of diborylmethane via a selective uni- and bidirectional method.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob02978k