Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors

Problem statement The aim of our study was to identify predictive factors for lymph node metastases (LNM) in children and adolescents with papillary thyroid carcinoma (PTC) and their impact on survival. Methods The authors conducted an Italian multicentric retrospective analysis on 132 pediatric pat...

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Bibliographic Details
Published in:World journal of surgery 2018-08, Vol.42 (8), p.2444-2453
Main Authors: Spinelli, C., Tognetti, F., Strambi, S., Morganti, R., Massimino, M., Collini, P.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adolescent
Adolescents
Biopsy
Carcinoma, Papillary - diagnostic imaging
Carcinoma, Papillary - secondary
Carcinoma, Papillary - surgery
Cardiac Surgery
Child
Child, Preschool
Children
Compartments
Demographic variables
Demographics
Disease-Free Survival
Female
General Surgery
Humans
Infiltration
Lymph Node Excision
Lymph nodes
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
Lymphatic system
Male
Medicine
Medicine & Public Health
Metastases
Metastasis
Neck
Neck - diagnostic imaging
Neoplasm Recurrence, Local - pathology
Original Scientific Report
Papillary thyroid carcinoma
Patients
Pediatrics
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Sex Distribution
Surgery
Survival
Teenagers
Thoracic Surgery
Thyroid
Thyroid cancer
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Ultrasonography
Vascular Surgery
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Summary:Problem statement The aim of our study was to identify predictive factors for lymph node metastases (LNM) in children and adolescents with papillary thyroid carcinoma (PTC) and their impact on survival. Methods The authors conducted an Italian multicentric retrospective analysis on 132 pediatric patients (0–18 years old) affected by PTC between 2000 and 2014. The investigated variables were demographic characteristics of the patients, clinicopathological features of PTCs, and persistence/recurrence of disease. The female/male ratio was 3.1:1. The median age was 14.3 ± 3.5 years (range 4–18 years). Total thyroidectomy was performed in all the patients, followed by lymph node dissection in 87 patients (65.9%). Metastatic lymph node involvement was confirmed in 73 patients (55.3%): lateral compartment (LC) in 25 patients (34.2%), central compartment (CC) in 17 patients (23.3%), and both compartments in 31 patients (42.5%). Results Multifocality ( P  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-018-4487-z