Vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected bone defects: An animal study

There is no consensus for the management of critical infected bone defects. The purpose of this study was to produce a vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected critical bone defects, and test it in a rabbit model. Electrospinning produced a res...

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Bibliographic Details
Published in:Journal of biomaterials applications 2018-04, Vol.32 (9), p.1187-1196
Main Authors: Wei, Shijun, Jian, Chao, Xu, Feng, Bao, Tongzhu, Lan, Shenghui, Wu, Gang, Qi, BaiWen, Bai, Zikui, Yu, Aixi
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Bone and Bones - microbiology
Bone and Bones - pathology
Drug Delivery Systems
Male
Membranes, Artificial
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
Osteomyelitis - pathology
Polyesters - chemistry
Rabbits
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcus aureus - drug effects
Vancomycin - administration & dosage
Vancomycin - therapeutic use
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Summary:There is no consensus for the management of critical infected bone defects. The purpose of this study was to produce a vancomycin–impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected critical bone defects, and test it in a rabbit model. Electrospinning produced a resorbable PCL fiber membrane containing vancomycin approximately 1 mm in thickness, with a pore diameter of
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328218754462