Zeolitic imidazolate framework-based biosensor for detection of HIV-1 DNA

ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concen...

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Bibliographic Details
Published in:Analytical biochemistry 2018-04, Vol.546, p.5-9
Main Authors: Pan, Yong, Zhan, Shenshan, Xia, Fan
Format: Article
Language:English
Subjects:
Adsorption
Biosensing Techniques
Biosensor
DNA, Viral - analysis
Fluorescence
Fluorescent Dyes - chemistry
HIV-1 - chemistry
HIV-1 - isolation & purification
HIV-1 DNA
Imidazoles - chemistry
Molecular Structure
Particle Size
Surface Properties
Zeolites - chemistry
Zinc-methylimidazolate framework-8
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Summary:ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concentration, the detection limit is as low as 1.2 nmol L−1 with good selectivity. This study is an important step toward rational design of materials to achieve specific interactions between biomolecules and synthetic particle surfaces.
ISSN:0003-2697
1096-0309
DOI:10.1016/j.ab.2018.01.017