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Clinical Assessment of Micro-residual Tumors during Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma
This study aimed to assess the need to consider microscopic invasion in terms of treatment planning in stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma and elucidate the appropriate clinical target volume (CTV) margin. A total of 121 patients (with 146 liver tumors) who underw...
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Published in: | Anticancer research 2018-02, Vol.38 (2), p.945-954 |
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container_issue | 2 |
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container_title | Anticancer research |
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creator | Uemoto, Kenji Doi, Hiroshi Shiomi, Hiroya Yamada, Koichi Tatsumi, Daisaku Yasumoto, Taku Takashina, Masaaki Koizumi, Masahiko Oh, Ryoong-Jin |
description | This study aimed to assess the need to consider microscopic invasion in terms of treatment planning in stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma and elucidate the appropriate clinical target volume (CTV) margin.
A total of 121 patients (with 146 liver tumors) who underwent SBRT between July 2007 and August 2016 were analyzed, regarding overall survival and local control (LC).
The 2- and 5-year LC rates were 91.5% and 89.8%, respectively. Planning target volume (PTV) margin |
doi_str_mv | 10.21873/anticanres.12308 |
format | article |
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A total of 121 patients (with 146 liver tumors) who underwent SBRT between July 2007 and August 2016 were analyzed, regarding overall survival and local control (LC).
The 2- and 5-year LC rates were 91.5% and 89.8%, respectively. Planning target volume (PTV) margin <8 mm was associated with poor LC. Of the 77 patients with PTV margin of <8 mm, age <75 years was associated with poor LC, while alpha-fetoprotein (AFP) ≤20 ng/ml was associated with good LC.
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A total of 121 patients (with 146 liver tumors) who underwent SBRT between July 2007 and August 2016 were analyzed, regarding overall survival and local control (LC).
The 2- and 5-year LC rates were 91.5% and 89.8%, respectively. Planning target volume (PTV) margin <8 mm was associated with poor LC. Of the 77 patients with PTV margin of <8 mm, age <75 years was associated with poor LC, while alpha-fetoprotein (AFP) ≤20 ng/ml was associated with good LC.
In patients with high AFP levels, there is a possibility of microscopic invasion around the tumor, suggesting that LC may be improved by adding an additional clinical target volume margin to the gross tumor volume.</description><subject>Background radiation</subject><subject>Hepatocellular carcinoma</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Patients</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Tumors</subject><subject>α-Fetoprotein</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUFv1DAQhS0EokvhB3BBlrhwSWtnEjs-llWhSK0qleUczdoTcJXYi-0c9t9j2gISpznMe2-e5mPsrRRnrRw0nGMo3mJIlM9kC2J4xjZSG9noHsRzthFtLxotRH_CXuV8L4RSZoCX7KQ1oDvdqg0r29mHmjHzi5wp54VC4XHiN96m2NRg79a63K1LTJm7NfnwnX8tlCgWtPU6_xjdkd-h81h8DHz3gxIejnyKiV_RAUu0NM_rjIlvMVkf4oKv2YsJ50xvnuYp-_bpcre9aq5vP3_ZXlw3FnRbGoVk0diJnJXdZBT1MBgpwAphuv1AwqmO0E4d6l4q7ZwCaXogZUU_dXsFp-zDY-4hxZ8r5TIuPv-ug4HimkdpDAgJSpgqff-f9D6uKdR2YytBS9kpgKqSj6r6nJwTTeMh-QXTcZRifEAy_kMyPiCpnndPyet-IffX8YcB_AKMeYuu</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Uemoto, Kenji</creator><creator>Doi, Hiroshi</creator><creator>Shiomi, Hiroya</creator><creator>Yamada, Koichi</creator><creator>Tatsumi, Daisaku</creator><creator>Yasumoto, Taku</creator><creator>Takashina, Masaaki</creator><creator>Koizumi, Masahiko</creator><creator>Oh, Ryoong-Jin</creator><general>International Institute of Anticancer Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Clinical Assessment of Micro-residual Tumors during Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma</title><author>Uemoto, Kenji ; 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A total of 121 patients (with 146 liver tumors) who underwent SBRT between July 2007 and August 2016 were analyzed, regarding overall survival and local control (LC).
The 2- and 5-year LC rates were 91.5% and 89.8%, respectively. Planning target volume (PTV) margin <8 mm was associated with poor LC. Of the 77 patients with PTV margin of <8 mm, age <75 years was associated with poor LC, while alpha-fetoprotein (AFP) ≤20 ng/ml was associated with good LC.
In patients with high AFP levels, there is a possibility of microscopic invasion around the tumor, suggesting that LC may be improved by adding an additional clinical target volume margin to the gross tumor volume.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>29374726</pmid><doi>10.21873/anticanres.12308</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Background radiation Hepatocellular carcinoma Liver Liver cancer Patients Radiation Radiation therapy Tumors α-Fetoprotein |
title | Clinical Assessment of Micro-residual Tumors during Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma |
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