NaHS prejunctionally inhibits the cardioaccelerator sympathetic outflow in pithed rats

Hydrogen sulfide is a gasotransmitter that mediates cardiovascular responses and could protect the heart from ischemia-reperfusion damage. Furthermore, this gas mediates bradycardia although the mechanisms involved remain elusive. In this regard, the inhibition of the cardiac sympathetic outflow may...

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Bibliographic Details
Published in:European journal of pharmacology 2018-03, Vol.823, p.35-40
Main Authors: Centurión, David, de la Cruz, Saúl Huerta, Castillo-Santiago, Shirley V., Becerril-Chacón, María Elena, Torres-Pérez, José A., Sánchez-López, Araceli
Format: Article
Language:English
Subjects:
(±)-noradrenaline bitartrate (PubChem ID: 297812)
Bradycardia
Gallamine triethiodide (PubChem ID: 6172)
Heart rate
Hydrogen sulfide
Isoproterenol hydrochloride (PubChem ID: 5807)
Neurotransmission
Sodium hydrosulfide monohydrate (PubChem ID: 28015)
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Summary:Hydrogen sulfide is a gasotransmitter that mediates cardiovascular responses and could protect the heart from ischemia-reperfusion damage. Furthermore, this gas mediates bradycardia although the mechanisms involved remain elusive. In this regard, the inhibition of the cardiac sympathetic outflow may be partially involved. Thus, this study was designed to determine the capability of NaHS to inhibit the tachycardic responses induced by preganglionic stimulation of the cardioaccelerator sympathetic outflow. Wistar rats were anaesthetized with isoflurane, cannulated and pithed. Then, animals received gallamine and the effect of i.v. infusion of NaHS (310 and 560 μg/kg min) was evaluated on the tachycardic responses induced by (1) sympathetic stimulation (0.1–3.2 Hz) at C7-T1 region of the vertebral column; or i.v. injections of (2) noradrenaline (0.03–3 μg/kg) and (3) isoproterenol (0.0003–0.1 μg/kg). Notably, NaHS significantly and dose-dependently inhibited the tachycardic responses induced by electrical stimulation of the preganglionic sympathetic outflow without significantly modify the tachycardic responses induced by either noradrenaline or isoproterenol. These results allow us to conclude that i.v. infusion of NaHS inhibited the tachycardic responses induced by stimulation of the cardioaccelerator sympathetic outflow by a prejunctional mechanism.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2018.01.030