Gold Nanoparticle-Collagen Gels for Soft Tissue Augmentation

Collagen soft tissue fillers suffer from fast reabsorption, which minimizes their use as a tissue-engineered construct. Extensive cross-linking can be utilized to extend longevity, but changes in microstructure and biomechanics can have deleterious effects. To enhance longevity while still achieving...

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Bibliographic Details
Published in:Tissue engineering. Part A 2018-07, Vol.24 (13-14), p.191-1098
Main Authors: Grant, Sheila A., Zhu, Jiaxun, Gootee, Jonathan, Snider, Colten L., Bellrichard, Mitch, Grant, David A.
Format: Article
Language:English
Subjects:
Acids
Animals
Binding sites
Biocompatibility
Bioengineering
Collagen
Collagen - chemistry
Cross-linking
Extracellular matrix
Fibroblasts
Filler materials
Gels
Gels - chemistry
Gold
Gold - chemistry
Hyaluronic acid
Implants, Experimental
Investigations
Irritation
Longevity
Mechanical properties
Metal Nanoparticles - chemistry
Nanocomposites
Nanomaterials
Nanoparticles
Necrosis
Original Articles
Reabsorption
Researchers
Swine
Tissue engineering
Tissue Engineering - methods
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Summary:Collagen soft tissue fillers suffer from fast reabsorption, which minimizes their use as a tissue-engineered construct. Extensive cross-linking can be utilized to extend longevity, but changes in microstructure and biomechanics can have deleterious effects. To enhance longevity while still achieving a natural microstructure, gold nanoparticles (AuNPs) were conjugated to fibrilized collagen and homogenized into an injectable form for use as a soft tissue filler. A long-term animal study in Yucatan swine was conducted to assess biocompatibility and longevity. Two formulations of the AuNP-collagen were compared to porcine cross-linked collagen and commercially available hyaluronic acid (HA). The results of the study demonstrated that the AuNPs may provide enhanced longevity over 6 months compared to HA and cross-linked collagen. Irritation scores indicated that the AuNP-collagen construct (AuNP-CC) demonstrated low irritation compared to the cross-linked collagen and HA while histology scores demonstrated good biocompatibility. Overall, it may be possible to utilize AuNPs to stabilize and increase the longevity of CC while still achieving biocompatibility.
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2017.0385