Leukemia risk in caprolactam workers exposed to benzene

To investigate the leukemia risk in a group of benzene exposed workers. We conducted a retrospective cohort mortality study on 311 men who worked between January 1, 1951 and December 31, 1968 in a Caprolactam plant in the Netherlands. In the production of Caprolactam (the Nylon 6 monomer) pure benze...

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Bibliographic Details
Published in:Annals of epidemiology 2005, Vol.15 (1), p.21-28
Main Authors: Swaen, Gerard M.H., Scheffers, Theo, de Cock, Johan, Slangen, Jos, Drooge, Hinkelien
Format: Article
Language:English
Subjects:
Algorithms
Benzene
Benzene - adverse effects
Caprolactam
Cause of Death
Chemical Industry
Cohort Studies
Epidemiology
Humans
Leukemia
Leukemia - epidemiology
Leukemia - mortality
Netherlands - epidemiology
Occupation
Occupational Exposure
Risk Assessment
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Summary:To investigate the leukemia risk in a group of benzene exposed workers. We conducted a retrospective cohort mortality study on 311 men who worked between January 1, 1951 and December 31, 1968 in a Caprolactam plant in the Netherlands. In the production of Caprolactam (the Nylon 6 monomer) pure benzene is used as an extracting agent and the workers at this plant have been exposed to substantial concentrations of benzene. The cohort was followed for mortality until January 1, 2001. The total mortality was below the expected number, which was mainly caused by a deficit of cardiovascular disease mortality. In the total group, there was one death from leukemia, compared with an expected number of 1.17. Despite the substantial exposures to benzene (on average 159 ppm-years per person) there was no indication for increased leukemia mortality within the cohort. We have applied earlier quantitative risk assessments to our cohort and conclude that some of these assessments overestimate the risk observed in our cohort of Caprolactam workers.
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2004.03.007