The Role of Interleukin-19 in Contact Hypersensitivity

• Published in: Biological & pharmaceutical bulletin 2018/02/01, Vol.41(2), pp.182-189
• Main Authors: Fujimoto, Yasuyuki, Fujita, Takashi, Kuramoto, Nobuyuki, Kuwamura, Mitsuru, Izawa, Takeshi, Nishiyama, Kazuhiro, Yoshida, Natsuho, Nakajima, Hidemitsu, Takeuchi, Tadayoshi, Azuma, Yasu-Taka
• Format: Article
• Language: English
• Subjects: Animals; anti-inflammatory cytokine; Cells, Cultured; Colitis; Contact dermatitis; Cytokines; Dermatitis, Contact - blood; Dermatitis, Contact - immunology; Dermatitis, Contact - metabolism; Dermatitis, Contact - pathology; Dinitrofluorobenzene; Dinitrofluorobenzene - analogs & derivatives; Dinitrofluorobenzene - toxicity; Ear; Gene Expression Regulation - drug effects; Haptens - toxicity; Hypersensitivity; IL-17; Immune system; Immunity, Innate - drug effects; Immunohistochemistry; Immunology; Inflammation; Innate immunity; Interferon; interleukin (IL)-19; Interleukin 10; Interleukin 17; Interleukin 19; Interleukin 4; Interleukin 6; Interleukin-17 - agonists; Interleukin-17 - genetics; Interleukin-17 - metabolism; Interleukin-6 - agonists; Interleukin-6 - genetics; Interleukin-6 - metabolism; Interleukins - agonists; Interleukins - blood; Interleukins - genetics; Interleukins - metabolism; Lymph nodes; Lymph Nodes - drug effects; Lymph Nodes - immunology; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphocytes; Lymphocytes T; Macrophages; Mice; Mice, Inbred BALB C; Mice, Knockout; RNA, Messenger - metabolism; Rodents; Skin; Skin - drug effects; Skin - immunology; Skin - metabolism; Skin - pathology; skin inflammation; Spleen - drug effects; Spleen - immunology; Spleen - metabolism; Spleen - pathology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; Th1 Cells - drug effects; Th1 Cells - immunology; Th1 Cells - metabolism; Th1 Cells - pathology
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b17-00594

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)γ and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS.