Bulleyaconitine A prevents Ti particle‐induced osteolysis via suppressing NF‐κB signal pathway during osteoclastogenesis and osteoblastogenesis

Balanced bone resorption and bone formation are vital for bone homeostasis. Excessive osteoclastic bone resorption in this process can cause a variety of bone disorders including osteoporosis, aseptic prosthetic loosening and tumor associated bone destruction. Bulleyaconitine A (BLA) is a natural co...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2018-09, Vol.233 (9), p.7067-7079
Main Authors: Zhang, Liwei, Feng, Mingxuan, Li, Zhiyan, Zhu, Min, Fan, Yongyong, Chu, Binxiang, Yuan, Chiting, Chen, Lihua, Lv, Haiyan, Hong, Zhenghua, Hong, Dun
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bone diseases
Bone growth
Bone loss
Bone resorption
Bone turnover
bulleyaconitine A
Gene expression
Homeostasis
Loosening
Mineralization
NF‐κB signal pathway
osteoblast
Osteoblastogenesis
osteoclast
Osteoclastogenesis
Osteoclasts
Osteogenesis
Osteolysis
Osteoporosis
Pain
Prostheses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Balanced bone resorption and bone formation are vital for bone homeostasis. Excessive osteoclastic bone resorption in this process can cause a variety of bone disorders including osteoporosis, aseptic prosthetic loosening and tumor associated bone destruction. Bulleyaconitine A (BLA) is a natural compound that has been widely used for pain treatment but its role in osteolysis has not yet been investigated. In this study, we verified for the first time that BLA inhibited osteoclast formation, the mRNA expression of osteoclast‐related genes and osteoclastic bone resorption by inhibiting NF‐κB signal pathway and downstream NFATc1 expression. Meanwhile, BLA had a stimulatory effect in osteoblast differentiation and mineralization. Furthermore, BLA showed preventive effect in Ti particle‐induced osteolysis model in vivo. Together, all our data demonstrated that BLA suppressed osteoclastogenesis and promoted osteoblastogenesis via suppressing NF‐κB signal pathway and could be an alternative therapeutic choice against bone loss. Bulleyaconitine A prevents Ti particle‐induced osteolysis by preventing osteoclast formation and promoting osteoblast differentiation.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26508