Ellagic acid in suppressing in vivo and in vitro oxidative stresses

Oxidative stress is a biological condition produced by a variety of factors, causing several chronic diseases. Oxidative stress was, therefore, treated with natural antioxidants, such as ellagic acid (EA). EA has a major role in protecting against different diseases associated with oxidative stress....

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2018-11, Vol.448 (1-2), p.27-41
Main Author: Zeb, Alam
Format: Article
Language:English
Subjects:
Antioxidants
Antioxidants (Nutrients)
Biochemistry
Biomedical and Life Sciences
Cardiology
Chronic diseases
Chronic illnesses
Diseases
Ellagic acid
Enzymes
In vivo methods and tests
Life Sciences
Medical Biochemistry
Oncology
Oxidation
Oxidative stress
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Summary:Oxidative stress is a biological condition produced by a variety of factors, causing several chronic diseases. Oxidative stress was, therefore, treated with natural antioxidants, such as ellagic acid (EA). EA has a major role in protecting against different diseases associated with oxidative stress. This review critically discussed the antioxidant role of EA in biological systems. The in vitro and in vivo studies have confirmed the protective role of EA in suppressing oxidative stress. The review also discussed the mechanism of EA in suppressing of oxidative stress, which showed that EA activates specific endogenous antioxidant enzymes and suppresses specific genes responsible for inflammation, diseases, or disturbance of biochemical systems. The amount of EA used and duration, which plays a significant role in the treatment of oxidative stress has been discussed. In conclusion, EA is a strong natural antioxidant, which possesses the suppressing power of oxidative stress in biological systems.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-018-3310-3