Developing Ovarian Follicles Inhibit the Endotoxin-Induced Glomerular Inflammatory Reaction in Pseudopregnant Rats

Problem:  We tested the hypothesis that developing ovarian follicles produce factors inhibiting the endotoxin induced inflammatory response. Method of study:  Pseudopregnant rats were treated with FSH to induced follicular development (FSH‐rats). For control we used untreated pseudopregnant rats (PS...

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Published in:American journal of reproductive immunology (1989) 2004-05, Vol.51 (5), p.385-389
Main Authors: Faas, Marijke M., Van Der Schaaf, Gerda, Moes, Henk, Heineman, Maas Jan, De Vos, Paul
Format: Article
Language:English
Subjects:
Animals
CD11a Antigen - metabolism
CD11b Antigen - metabolism
Cell Count
Endotoxin
Endotoxins - pharmacology
Female
Follicle Stimulating Hormone - pharmacology
Follicular Phase - physiology
Glomerulonephritis - chemically induced
Glomerulonephritis - pathology
Granulocytes - cytology
Immunohistochemistry
inflammation
Intercellular Adhesion Molecule-1 - metabolism
Kidney Glomerulus - drug effects
Kidney Glomerulus - metabolism
Kidney Glomerulus - pathology
monocytes
Monocytes - cytology
Ovarian Follicle - growth & development
Ovarian Follicle - physiology
ovary
Ovary - anatomy & histology
Ovary - drug effects
Progesterone - blood
Pseudopregnancy - physiopathology
Rats
Rats, Wistar
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Summary:Problem:  We tested the hypothesis that developing ovarian follicles produce factors inhibiting the endotoxin induced inflammatory response. Method of study:  Pseudopregnant rats were treated with FSH to induced follicular development (FSH‐rats). For control we used untreated pseudopregnant rats (PSP‐rats) and rats in the follicular phase of the ovarian cycle (C‐rats). All rats were infused with either saline or endotoxin. Three days after the infusion rats were sacrificed and kidney specimens were snapfrozen. Cryostat kidney sections were stained for the presence of monocytes, granulocytes, CD11a‐ and CD11b‐positive cells and for ICAM‐1 expression. Results:  The results show that induction of follicular development in pseudopregnant rats inhibited glomerular infiltration of monocytes and CD11b+ cells, while it did not affect the other parameters, i.e. glomerular granulocyte number, CD11a+ cells and glomerular ICAM‐1 expression. Conclusion:  Developing ovarian follicles produce factors inhibiting monocyte responses to endotoxin.
ISSN:1046-7408
1600-0897
DOI:10.1111/j.1600-0897.2004.00173.x