Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A) 2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and rev...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (15), p.1897-19
Main Authors: Saintomé, C, Alberti, P, Guinot, N, Lejault, P, Chatain, J, Mailliet, P, Riou, J.-F, Bugaut, A
Format: Article
Language:English
Subjects:
Chemical Sciences
Deoxyribonucleic acid
DNA
Ligands
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A) 2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA. A new dimeric ligand binds telomeric contiguous G4s, displacing the single-stranded DNA binding RPA more efficiently than its monomeric counterpart.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07048a