Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy

Platinum‐based chemotherapy agents are widely used in the treatment of various solid malignancies. However, their efficacy is limited by drug resistance. Recent studies suggest that copper efflux transporters, which are encoded by ATP7A and ATP7B, play an important role in platinum drug resistance....

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Bibliographic Details
Published in:IUBMB life 2018-03, Vol.70 (3), p.183-191
Main Authors: Li, Yue‐Qin, Yin, Ji‐Ye, Liu, Zhao‐Qian, Li, Xiang‐Ping
Format: Article
Language:English
Subjects:
ATP7A
ATP7B
Biomarkers, Tumor - genetics
Cancer
Chemotherapy
Copper
Copper-transporting ATPases - genetics
Drug resistance
Drug Resistance, Neoplasm - genetics
Humans
Medical prognosis
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Platinum
Platinum - adverse effects
Platinum - therapeutic use
platinum‐based chemotherapy
tumorigenesis
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Summary:Platinum‐based chemotherapy agents are widely used in the treatment of various solid malignancies. However, their efficacy is limited by drug resistance. Recent studies suggest that copper efflux transporters, which are encoded by ATP7A and ATP7B, play an important role in platinum drug resistance. Over‐expressions of ATP7A and ATP7B are observed in multiple cancers. Moreover, their expressions are associated with cancer prognosis and treatment outcomes of platinum‐based chemotherapy. In our review, we highlight the roles of ATP7A/7B in platinum drug resistance and cancer progression. We also discuss the possible mechanisms of platinum drug resistance mediated by ATP7A/7B and provide novel strategies for overcoming resistance. This review may be helpful for understanding the roles of ATP7A and ATP7B in platinum drug resistance. © 2018 IUBMB Life, 70(3):183–191, 2018
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1722