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The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact
Introduction Approximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resect...
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| Published in: | Irish journal of medical science 2018-11, Vol.187 (4), p.1009-1020 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1020 |
| container_issue | 4 |
| container_start_page | 1009 |
| container_title | Irish journal of medical science |
| container_volume | 187 |
| creator | Tasleem, Sadia Bolger, Jarlath C. Kelly, Michael E. Boland, Michael R. Bowden, Dermot Sweeney, Karl J. Malone, Carmel |
| description | Introduction
Approximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resected, this is not yet the standard of care for breast cancer-related liver metastases. This review examines the evidence for resection of breast cancer-related liver metastases.
Methods
A systematic review identified 25 articles for inclusion, 12 papers concerning patients with isolated liver metastases, and 13 papers concerning patients with extrahepatic metastases. Data from 1080 patients were included.
Results
Two hundred eighty patients underwent hepatic resections for breast cancer-associated metastases with no extrahepatic metastases. Reported 5-year survival ranged from 24.6 to 78%. Median overall survival ranged from 29.5 to 116 months. For patients with oligometastatic disease undergoing resection, 5-year survival ranged from 21 to 57%, with median overall survival ranging from 32 to 58 months. Reported 30-day morbidity ranged from 14 to 42% for isolated and multiple metastases.
Conclusion
Hepatic resection can be considered in the management of breast cancer patients with isolated liver metastases as well as those with oligometastatic disease. |
| doi_str_mv | 10.1007/s11845-018-1746-9 |
| format | article |
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Approximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resected, this is not yet the standard of care for breast cancer-related liver metastases. This review examines the evidence for resection of breast cancer-related liver metastases.
Methods
A systematic review identified 25 articles for inclusion, 12 papers concerning patients with isolated liver metastases, and 13 papers concerning patients with extrahepatic metastases. Data from 1080 patients were included.
Results
Two hundred eighty patients underwent hepatic resections for breast cancer-associated metastases with no extrahepatic metastases. Reported 5-year survival ranged from 24.6 to 78%. Median overall survival ranged from 29.5 to 116 months. For patients with oligometastatic disease undergoing resection, 5-year survival ranged from 21 to 57%, with median overall survival ranging from 32 to 58 months. Reported 30-day morbidity ranged from 14 to 42% for isolated and multiple metastases.
Conclusion
Hepatic resection can be considered in the management of breast cancer patients with isolated liver metastases as well as those with oligometastatic disease.</description><identifier>ISSN: 0021-1265</identifier><identifier>EISSN: 1863-4362</identifier><identifier>DOI: 10.1007/s11845-018-1746-9</identifier><identifier>PMID: 29392651</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Family Medicine ; Female ; General Practice ; Hepatectomy - methods ; Humans ; Internal Medicine ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Medicine ; Medicine & Public Health ; Middle Aged ; Review Article ; Survival Rate ; Treatment Outcome</subject><ispartof>Irish journal of medical science, 2018-11, Vol.187 (4), p.1009-1020</ispartof><rights>Royal Academy of Medicine in Ireland 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-f58a53b5ddecf7059e21fa42eea73f64eaf1c5ec62f5d29b09ba52da69089c323</citedby><cites>FETCH-LOGICAL-c344t-f58a53b5ddecf7059e21fa42eea73f64eaf1c5ec62f5d29b09ba52da69089c323</cites><orcidid>0000-0002-0796-633X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29392651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tasleem, Sadia</creatorcontrib><creatorcontrib>Bolger, Jarlath C.</creatorcontrib><creatorcontrib>Kelly, Michael E.</creatorcontrib><creatorcontrib>Boland, Michael R.</creatorcontrib><creatorcontrib>Bowden, Dermot</creatorcontrib><creatorcontrib>Sweeney, Karl J.</creatorcontrib><creatorcontrib>Malone, Carmel</creatorcontrib><title>The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact</title><title>Irish journal of medical science</title><addtitle>Ir J Med Sci</addtitle><addtitle>Ir J Med Sci</addtitle><description>Introduction
Approximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resected, this is not yet the standard of care for breast cancer-related liver metastases. This review examines the evidence for resection of breast cancer-related liver metastases.
Methods
A systematic review identified 25 articles for inclusion, 12 papers concerning patients with isolated liver metastases, and 13 papers concerning patients with extrahepatic metastases. Data from 1080 patients were included.
Results
Two hundred eighty patients underwent hepatic resections for breast cancer-associated metastases with no extrahepatic metastases. Reported 5-year survival ranged from 24.6 to 78%. Median overall survival ranged from 29.5 to 116 months. For patients with oligometastatic disease undergoing resection, 5-year survival ranged from 21 to 57%, with median overall survival ranging from 32 to 58 months. Reported 30-day morbidity ranged from 14 to 42% for isolated and multiple metastases.
Conclusion
Hepatic resection can be considered in the management of breast cancer patients with isolated liver metastases as well as those with oligometastatic disease.</description><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Review Article</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0021-1265</issn><issn>1863-4362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPxSAQhYnR6PXxA9wYlm6qPAot7ozxlZi40TWhdFBMS69Ar_rvRa-6dDWTOWfOZD6EDik5oYQ0p4nSthYVoW1Fm1pWagMtaCt5VXPJNtGCEEYryqTYQbspvRDCFZf1Ntphiqsypgv0_vAMOE4D4Mnhwa8g4ggJbPZTwD7gpckeQk74zednPEI2KZeRxV2E0mJrgoV4hg1OHynD-K1FWHl4w_BuRh98eMK5HElzXPmVGbAfl8bmfbTlzJDg4Kfuocery4eLm-ru_vr24vyusryuc-VEawTvRN-DdQ0RChh1pmYApuFO1mActQKsZE70THVEdUaw3khFWmU543voeJ27jNPrDCnr0ScLw2ACTHPSVBUWqiGSFytdW22cUorg9DL60cQPTYn-Aq7XwHUBrr-Aa1V2jn7i526E_m_jl3AxsLUhFSk8QdQv0xxDefmf1E_pEI5s</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Tasleem, Sadia</creator><creator>Bolger, Jarlath C.</creator><creator>Kelly, Michael E.</creator><creator>Boland, Michael R.</creator><creator>Bowden, Dermot</creator><creator>Sweeney, Karl J.</creator><creator>Malone, Carmel</creator><general>Springer London</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0796-633X</orcidid></search><sort><creationdate>20181101</creationdate><title>The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact</title><author>Tasleem, Sadia ; Bolger, Jarlath C. ; Kelly, Michael E. ; Boland, Michael R. ; Bowden, Dermot ; Sweeney, Karl J. ; Malone, Carmel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-f58a53b5ddecf7059e21fa42eea73f64eaf1c5ec62f5d29b09ba52da69089c323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Review Article</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tasleem, Sadia</creatorcontrib><creatorcontrib>Bolger, Jarlath C.</creatorcontrib><creatorcontrib>Kelly, Michael E.</creatorcontrib><creatorcontrib>Boland, Michael R.</creatorcontrib><creatorcontrib>Bowden, Dermot</creatorcontrib><creatorcontrib>Sweeney, Karl J.</creatorcontrib><creatorcontrib>Malone, Carmel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Irish journal of medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tasleem, Sadia</au><au>Bolger, Jarlath C.</au><au>Kelly, Michael E.</au><au>Boland, Michael R.</au><au>Bowden, Dermot</au><au>Sweeney, Karl J.</au><au>Malone, Carmel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact</atitle><jtitle>Irish journal of medical science</jtitle><stitle>Ir J Med Sci</stitle><addtitle>Ir J Med Sci</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>187</volume><issue>4</issue><spage>1009</spage><epage>1020</epage><pages>1009-1020</pages><issn>0021-1265</issn><eissn>1863-4362</eissn><abstract>Introduction
Approximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resected, this is not yet the standard of care for breast cancer-related liver metastases. This review examines the evidence for resection of breast cancer-related liver metastases.
Methods
A systematic review identified 25 articles for inclusion, 12 papers concerning patients with isolated liver metastases, and 13 papers concerning patients with extrahepatic metastases. Data from 1080 patients were included.
Results
Two hundred eighty patients underwent hepatic resections for breast cancer-associated metastases with no extrahepatic metastases. Reported 5-year survival ranged from 24.6 to 78%. Median overall survival ranged from 29.5 to 116 months. For patients with oligometastatic disease undergoing resection, 5-year survival ranged from 21 to 57%, with median overall survival ranging from 32 to 58 months. Reported 30-day morbidity ranged from 14 to 42% for isolated and multiple metastases.
Conclusion
Hepatic resection can be considered in the management of breast cancer patients with isolated liver metastases as well as those with oligometastatic disease.</abstract><cop>London</cop><pub>Springer London</pub><pmid>29392651</pmid><doi>10.1007/s11845-018-1746-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0796-633X</orcidid></addata></record> |
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| ispartof | Irish journal of medical science, 2018-11, Vol.187 (4), p.1009-1020 |
| issn | 0021-1265 1863-4362 |
| language | eng |
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| source | Springer Link |
| subjects | Breast Neoplasms - mortality Breast Neoplasms - pathology Family Medicine Female General Practice Hepatectomy - methods Humans Internal Medicine Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - surgery Medicine Medicine & Public Health Middle Aged Review Article Survival Rate Treatment Outcome |
| title | The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact |
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