Insular multiple sclerosis lesions are associated with erectile dysfunction

Erectile function (EF) is frequently compromised in men with multiple sclerosis (MS). Functional neuroimaging in healthy men identified a network of brain areas, such as the insula, visual and somatosensory association areas, cingulate gyrus, prefrontal cortex, as well as subcortical regions, contri...

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Bibliographic Details
Published in:Journal of neurology 2018-04, Vol.265 (4), p.783-792
Main Authors: Winder, Klemens, Linker, Ralf A., Seifert, Frank, Deutsch, Martina, Engelhorn, Tobias, Dörfler, Arnd, Lee, De-Hyung, Hösl, Katharina M., Hilz, Max J.
Format: Article
Language:English
Subjects:
Age
Erectile dysfunction
Intestine
Magnetic resonance imaging
Medicine
Medicine & Public Health
Multiple sclerosis
Neuroimaging
Neurology
Neuroradiology
Neurosciences
NMR
Nuclear magnetic resonance
Original Communication
Prefrontal cortex
Sexual behavior
Somatosensory cortex
Urinary bladder
Visual cortex
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Summary:Erectile function (EF) is frequently compromised in men with multiple sclerosis (MS). Functional neuroimaging in healthy men identified a network of brain areas, such as the insula, visual and somatosensory association areas, cingulate gyrus, prefrontal cortex, as well as subcortical regions, contributing to EF. This study intended to determine associations between EF deterioration during MS and cerebral MS-associated lesion sites. In 31 men with MS (mean age 38.2 ± 11.2 years), we evaluated MS-related EF deterioration by comparing scores of the 5-item International Index of Erectile Function-5 questionnaire (IIEF5) at the time of study and retrospectively, 3 months prior to MS diagnosis, by calculating score differences as DeltaIIEF5 (DeltaIIEF5 score 
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-018-8763-5