Diagnostic performance of diffusion-weighted MR imaging at 3.0 T in predicting muscle invasion in urinary bladder cancer: utility of evaluating the morphology of the reactive tumor stalk

Purpose To evaluate the diagnostic performance of stalk morphology on diffusion-weighted imaging (DWI) in comparison with conventional MRI in predicting muscle invasion in urinary bladder cancer. Methods The study was prospective and approved by the institutional ethics committee. A written informed...

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Bibliographic Details
Published in:Abdominal imaging 2018-09, Vol.43 (9), p.2431-2441
Main Authors: Razik, Abdul, Das, Chandan J., Sharma, Sanjay, Seth, Amlesh, Srivastava, Deep N., Mathur, Sandeep, Kumar, Rakesh, Gupta, Arun K.
Format: Article
Language:English
Subjects:
Bladder
Bladder cancer
Cancer
Criteria
Diagnostic systems
Distension
Ethics
Gastroenterology
Hepatology
Histopathology
Imaging
Infiltration
Informed consent
Invasiveness
Magnetic resonance imaging
Medical diagnosis
Medicine
Medicine & Public Health
Metastases
Morphology
Muscles
Patients
Performance indices
Performance prediction
Radiology
Tumors
Urinary bladder
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Summary:Purpose To evaluate the diagnostic performance of stalk morphology on diffusion-weighted imaging (DWI) in comparison with conventional MRI in predicting muscle invasion in urinary bladder cancer. Methods The study was prospective and approved by the institutional ethics committee. A written informed consent was obtained from all the patients. The study included 56 patients who presented with bladder mass between January 2014 and November 2015. After excluding 16 patients, 40 patients with 92 tumors were assessed. All the 40 patients underwent MRI at 3.0 Tesla (Achieva, Philips) inclusive of DWI (b0, 500, 1000 and 1500). Two radiologists evaluated the images independently, and disparities were resolved through consensus. For predicting muscle invasion on T2-weighted images, tumor morphology (papillary versus non-papillary), distensibility of the underlying bladder wall, and perivesical fat infiltration were evaluated. On DWI, the criterion used in a previous study (Takeuchi et al.) was used along with tumor stalk morphology. Findings were compared with histopathology using Pearson’s χ 2 test, and diagnostic performance indices were calculated. Results All the evaluated features were present with significantly higher frequency in muscle-invasive tumors ( p  
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-018-1458-7