Transcriptomic profiling of Clostridium difficile grown under microaerophillic conditions

Clostridium difficile (Cd) is an anaerobic, spore-forming bacterium capable of colonizing the gastrointestinal tract of humans. Colonization usually occurs following antibiotic-induced disruption of the host microbiota, which also leads to an increase in oxygen within the gastrointestinal tract. We...

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Bibliographic Details
Published in:Pathogens and disease 2018-03, Vol.76 (2)
Main Authors: Giordano, Nicole, Hastie, Jessica L, Carlson, Paul E
Format: Article
Language:English
Subjects:
Anaerobic conditions
Antibiotics
Cellular stress response
Clostridium difficile
Colonization
Disruption
Gastrointestinal system
Gastrointestinal tract
Gene expression
Gene regulation
Metabolism
Microbiota
Oxygen
Pathogenesis
Pyruvic acid
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Summary:Clostridium difficile (Cd) is an anaerobic, spore-forming bacterium capable of colonizing the gastrointestinal tract of humans. Colonization usually occurs following antibiotic-induced disruption of the host microbiota, which also leads to an increase in oxygen within the gastrointestinal tract. We sought to understand how Cd responds to this microaerophilic condition that is likely experienced within the host. Transcriptome profiling showed differential regulation of genes involved in sugar metabolism, pyruvate metabolism and stress responses. These data provide insight into potential mechanisms of Cd adaptation to the host environment and should lead to the elucidation unknown mechanisms of Cd oxygen resistance and pathogenesis.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/fty010