Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage?

Kondrashova, T.V. and Ivanova, T.I. Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage? Peripheral blood samples from seven healthy donors were exposed to 2 Gy of60Co gamma rays. Lymphocyte cultures were prepared from the samples and stimulated to proliferate either...

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Bibliographic Details
Published in:Radiation research 2000-01, Vol.153 (1), p.122-124
Main Authors: Kondrashova, T V, Ivanova, TI
Format: Article
Language:English
Online Access:Get full text
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Summary:Kondrashova, T.V. and Ivanova, T.I. Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage? Peripheral blood samples from seven healthy donors were exposed to 2 Gy of60Co gamma rays. Lymphocyte cultures were prepared from the samples and stimulated to proliferate either immediately after the exposure or after 1, 2 or 4 h. No significant differences were found between the frequencies of chromosome aberrations (breaks or exchange) observed in lymphocytes stimulated after different postirradiation periods. We conclude that unstimulated lymphocytes do not undergo significant levels of recovery from potentially lethal damage at the chromosomal level.
ISSN:0033-7587
DOI:10.1043/0033-7587(2000)153<0122:DQHPLR>2.0.CO;2