Hypertriglyceridemia and omega-3 fatty acids: Their often overlooked role in cardiovascular disease prevention

This review aims to describe the pathogenic role of triglycerides in cardiometabolic risk, and the potential role of omega-3 fatty acids in the management of hypertriglyceridemia and cardiovascular disease. In epidemiological studies, hypertriglyceridemia correlates with an increased risk of cardiov...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2018-03, Vol.28 (3), p.197-205
Main Authors: Arca, M., Borghi, C., Pontremoli, R., De Ferrari, G.M., Colivicchi, F., Desideri, G., Temporelli, P.L.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Dietary Supplements - adverse effects
Fatty Acids, Omega-3 - adverse effects
Fatty Acids, Omega-3 - therapeutic use
Humans
Hypertriglyceridemia
Hypertriglyceridemia - blood
Hypertriglyceridemia - diagnosis
Hypertriglyceridemia - drug therapy
Hypertriglyceridemia - epidemiology
Omega-3 fatty acids
Protective Factors
Risk Factors
Treatment Outcome
Triglycerides
Triglycerides - blood
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Summary:This review aims to describe the pathogenic role of triglycerides in cardiometabolic risk, and the potential role of omega-3 fatty acids in the management of hypertriglyceridemia and cardiovascular disease. In epidemiological studies, hypertriglyceridemia correlates with an increased risk of cardiovascular disease, even after adjustment for low density lipoprotein cholesterol (LDL-C) levels. This has been further supported by Mendelian randomization studies where triglyceride-raising common single nucleotide polymorphisms confer an increased risk of developing cardiovascular disease. Although guidelines vary in their definition of hypertriglyceridemia, they consistently define a normal triglyceride level as
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2017.11.001