Nonalcoholic fatty liver disease as a sentinel marker for the development of diabetes mellitus in non-obese subjects

Non alcoholic fatty liver disease (NAFLD) is associated with substantial cardiometabolic morbidity. We evaluated the long-term extrahepatic complications of NAFLD and sought to evaluate NAFLD in non-obese subjects. A total of 2920 participants were retrospectively selected from a health check-up cen...

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Bibliographic Details
Published in:Digestive and liver disease 2018-04, Vol.50 (4), p.370-377
Main Authors: Kim, Soon Sun, Cho, Hyo Jung, Kim, Hyun Ji, Kang, Dae Ryong, Berry, Jacob R., Kim, Jin Hong, Yang, Min Jae, Lim, Sun Gyo, Kim, SooJin, Cheong, Jae Youn, Cho, Sung Won
Format: Article
Language:English
Subjects:
Insulin resistance
Metabolic syndrome
Obesity
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Summary:Non alcoholic fatty liver disease (NAFLD) is associated with substantial cardiometabolic morbidity. We evaluated the long-term extrahepatic complications of NAFLD and sought to evaluate NAFLD in non-obese subjects. A total of 2920 participants were retrospectively selected from a health check-up center in 2000, and followed through to December 2010. NAFLD was diagnosed using ultrasonography. Subjects were stratified according to body mass index, NAFLD, and metabolic syndrome. The prevalence of non-obese NAFLD subjects and metabolically unhealthy non-obese subjects was 14.4% and 8.7%, respectively. In the multivariate analysis, non-obese NAFLD subjects had a significantly higher risk for diabetes mellitus (DM; HR 2.69, 95% CI 1.72–4.20, P 
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2017.12.018