The ubiquitin proteasome pathway in neuropsychiatric disorders

•The ubiquitin proteasome system (UPS) tightly regulates cellular protein turnover.•UPS function and regulation is essential for normal brain development.•Genes encoding members of the UPS are mutated in neurodevelopmental disorders.•Modulating the UPS presents a therapeutic opportunity for many neu...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiology of learning and memory 2019-11, Vol.165, p.106791-106791, Article 106791
Main Authors: Cheon, Solmi, Dean, Milan, Chahrour, Maria
Format: Article
Language:English
Subjects:
Autism spectrum disorder
Neuropsychiatric disorders
Proteasome pathway
Ubiquitin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The ubiquitin proteasome system (UPS) tightly regulates cellular protein turnover.•UPS function and regulation is essential for normal brain development.•Genes encoding members of the UPS are mutated in neurodevelopmental disorders.•Modulating the UPS presents a therapeutic opportunity for many neurological disorders. The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2018.01.012