trans-Golgi network-bound cargo traffic

Cargo following the retrograde trafficking are sorted at endosomes to be targeted the trans-Golgi network (TGN), a central receiving organelle. Though molecular requirements and their interaction networks have been somewhat established, the complete understanding of the intricate nature of their act...

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Bibliographic Details
Published in:European journal of cell biology 2018-04, Vol.97 (3), p.137-149
Main Authors: Makaraci, Pelin, Kim, Kyoungtae
Format: Article
Language:English
Subjects:
Cargo
Dynamin
Endosome
Fission
Fusion
Tether
trans-Golgi network
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Summary:Cargo following the retrograde trafficking are sorted at endosomes to be targeted the trans-Golgi network (TGN), a central receiving organelle. Though molecular requirements and their interaction networks have been somewhat established, the complete understanding of the intricate nature of their action mechanisms in every step of the retrograde traffic pathway remains unachieved. This review focuses on elucidating known functions of key regulators, including scission factors at the endosome and tethering/fusion mediators at the receiving dock, TGN, as well as a diverse range of cargo.
ISSN:0171-9335
1618-1298
DOI:10.1016/j.ejcb.2018.01.003