Bicuspid aortic valve morphology and its impact on aortic diameters—A systematic review with meta‐analysis and meta‐regression

Aim To evaluate the impact of the 2 most common bicuspid aortic valve (BAV) morphology patterns [right‐left (RL) vs right‐noncoronary (RN) cusp fusion] on the aortic diameters and the impact of gender, aortic stenosis (AS), aortic regurgitation (AR), and age on the observed effects. Methods The PubM...

Full description

Saved in:
Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2018-05, Vol.35 (5), p.667-677
Main Authors: Miśkowiec, Dawid, Lipiec, Piotr, Szymczyk, Ewa, Wejner‐Mik, Paulina, Michalski, Błażej, Kupczyńska, Karolina, Wierzbowska‐Drabik, Karina, Kasprzak, Jarosław D.
Format: Article
Language:English
Subjects:
aorta
Aorta - diagnostic imaging
aortic diameter
Aortic Valve - abnormalities
Aortic Valve - diagnostic imaging
aortic valve disease
aortopathy
bicuspid aortic valve
Bicuspid Aortic Valve Disease
echocardiography
Echocardiography - methods
Heart Valve Diseases - diagnosis
Humans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim To evaluate the impact of the 2 most common bicuspid aortic valve (BAV) morphology patterns [right‐left (RL) vs right‐noncoronary (RN) cusp fusion] on the aortic diameters and the impact of gender, aortic stenosis (AS), aortic regurgitation (AR), and age on the observed effects. Methods The PubMed databases was searched up to December 31, 2016 to identify studies investigating the morphology of BAV and aortic diameters. Inclusion criteria were as follows: the data on diameter of sinuses of Valsalva (SVD) and/or ascending aorta (AAD) and BAV morphology. The additional characteristics [gender, AS and AR (% of patients with moderate or severe AS/AR) and mean age] were collected to perform a meta‐regression analysis. Results A total of 12 studies with 2192 patients with indexed AAD, 15 studies with 3104 patients with nonindexed AAD and 8 studies with 1271 patients with indexed SVD, and 16 studies with 3454 patients with nonindexed SVD were included. There was no difference between RL and RN group in indexed/nonindexed AAD—mean difference (MD): 0.06 mm/m2 (95% CI: −0.65 to 0.77 mm/m2, P = .87) and −0.06 mm (95% CI: 1.10–0.97 mm, P = .91). Differently, the RL BAV was associated with larger indexed/nonindexed SVD than RN phenotype—MD: 1.66 mm/m2 (95% CI: 0.83–2.49 mm/m2, P 
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.13818