Extracellular proteases of Staphylococcus epidermidis: roles as virulence factors and their participation in biofilm

Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to th...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2018-03, Vol.126 (3), p.177-185
Main Authors: Martínez‐García, Sergio, Rodríguez‐Martínez, Sandra, Cancino‐Diaz, Mario E., Cancino‐Diaz, Juan C.
Format: Article
Language:English
Subjects:
Bacterial Proteins - metabolism
biofilm
Biofilms
Biofilms - growth & development
Cell Adhesion Molecules - metabolism
Cross Infection - microbiology
Cross Infection - pathology
Cysteine Proteases - metabolism
Cysteine proteinase
Deactivation
EcpA
Esp
Humans
Inactivation
Medical devices
Medical equipment
Metalloendopeptidases - metabolism
Metalloproteinase
Nosocomial infection
Pathogenicity
Pathogens
Protease
Proteases
Proteolysis
SepA
Serine
Serine Proteases - metabolism
Serine proteinase
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcus epidermidis
Staphylococcus epidermidis - enzymology
Staphylococcus epidermidis - metabolism
Staphylococcus epidermidis - pathogenicity
Substrate specificity
Substrates
Virulence
Virulence factors
Virulence Factors - metabolism
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Summary:Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to the different stages of biofilm formation. S. epidermidis secretes a small number of extracellular proteases, such as serine protease Esp, cysteine protease EcpA, and metalloprotease SepA that have a relatively low substrate specificity. Recent findings indicate a significant contribution of extracellular proteases in biofilm formation through the proteolytic inactivation of adhesion molecules. The objective of this work is to provide an overview of the current knowledge of S. epidermidis’ extracellular proteases during pathogenicity, especially in the different stages of biofilm formation.
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12805