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Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives
N-Alkyl and N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds 4d and 6a were found to be very less toxic to human...
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| Published in: | Bioorganic & medicinal chemistry 2006-03, Vol.14 (6), p.1819-1826 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c412t-628bad97165d73746c643a4e1b7e186eaa78c313983bec1b8bcaa715032750da3 |
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| cites | cdi_FETCH-LOGICAL-c412t-628bad97165d73746c643a4e1b7e186eaa78c313983bec1b8bcaa715032750da3 |
| container_end_page | 1826 |
| container_issue | 6 |
| container_start_page | 1819 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 14 |
| creator | Chaudhary, Preeti Kumar, Rupesh Verma, Akhilesh K. Singh, Devender Yadav, Vibha Chhillar, Anil K. Sharma, G.L. Chandra, Ramesh |
| description | N-Alkyl and
N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds
4d and
6a were found to be very less toxic to human erythrocytes when compared with gentamicin.
A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against
Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),
Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli (MTCCB 1652), and antifungal activity against
Aspergillus fumigatus,
Aspergillus flavus and
Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds
4d and
6a showed very less toxicity against human erythrocytes. |
| doi_str_mv | 10.1016/j.bmc.2005.10.032 |
| format | article |
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N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds
4d and
6a were found to be very less toxic to human erythrocytes when compared with gentamicin.
A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against
Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),
Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli (MTCCB 1652), and antifungal activity against
Aspergillus fumigatus,
Aspergillus flavus and
Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds
4d and
6a showed very less toxicity against human erythrocytes.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2005.10.032</identifier><identifier>PMID: 16289939</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antibacterial ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal ; Antifungal agents ; Aspergillus flavus ; Aspergillus fumigatus ; Aspergillus niger ; Bacteria - drug effects ; Biological and medical sciences ; Cytotoxicity ; Erythrocytes - drug effects ; Escherichia coli ; Fungi - drug effects ; General aspects ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Structure ; Pharmacology. Drug treatments ; Piperazine ; Piperazines - chemical synthesis ; Piperazines - chemistry ; Piperazines - pharmacology ; Pseudomonas aeruginosa ; Staphylococcus aureus ; Streptomyces</subject><ispartof>Bioorganic & medicinal chemistry, 2006-03, Vol.14 (6), p.1819-1826</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-628bad97165d73746c643a4e1b7e186eaa78c313983bec1b8bcaa715032750da3</citedby><cites>FETCH-LOGICAL-c412t-628bad97165d73746c643a4e1b7e186eaa78c313983bec1b8bcaa715032750da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17586034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16289939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaudhary, Preeti</creatorcontrib><creatorcontrib>Kumar, Rupesh</creatorcontrib><creatorcontrib>Verma, Akhilesh K.</creatorcontrib><creatorcontrib>Singh, Devender</creatorcontrib><creatorcontrib>Yadav, Vibha</creatorcontrib><creatorcontrib>Chhillar, Anil K.</creatorcontrib><creatorcontrib>Sharma, G.L.</creatorcontrib><creatorcontrib>Chandra, Ramesh</creatorcontrib><title>Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>N-Alkyl and
N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds
4d and
6a were found to be very less toxic to human erythrocytes when compared with gentamicin.
A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against
Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),
Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli (MTCCB 1652), and antifungal activity against
Aspergillus fumigatus,
Aspergillus flavus and
Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds
4d and
6a showed very less toxicity against human erythrocytes.</description><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal</subject><subject>Antifungal agents</subject><subject>Aspergillus flavus</subject><subject>Aspergillus fumigatus</subject><subject>Aspergillus niger</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity</subject><subject>Erythrocytes - drug effects</subject><subject>Escherichia coli</subject><subject>Fungi - drug effects</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperazine</subject><subject>Piperazines - chemical synthesis</subject><subject>Piperazines - chemistry</subject><subject>Piperazines - pharmacology</subject><subject>Pseudomonas aeruginosa</subject><subject>Staphylococcus aureus</subject><subject>Streptomyces</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEgvHxA7igXuDWETdp2ogTmviSEAgB5yhNPZHRj5F0k8avx2OTuHGw7FiPHb8vY6fAx8BBXc7GVevGGec5vcdcZDtsBFLJVAgNu2zEtSpTXmp1wA5jnHHOM6lhnx2AykqthR6xl9dVN3xg9DGxXU0x-Na70FfeNol1g1_6YZX00-Qptc3nqvmlqA5Uzv0cg_32HSY1Br-0RGM8ZntT20Q82eYj9n578za5Tx-f7x4m14-pk5ANKV1Q2VoXoPK6EIVUTklhJUJVIJQKrS1KJ0DoUlTooCorRy3ISWWR89qKI3ax2TsP_dcC42BaHx02je2wX0QDWueZBCAQNiDJijHg1MyDb0mBAW7WPpqZIR_N2sd1i36gmbPt8kXVYv03sTWOgPMtYKOzzTTYzvn4xxV5qbiQxF1tOCQrlh6Dic5j57D2Ad1g6t7_c8YP9byQAg</recordid><startdate>20060315</startdate><enddate>20060315</enddate><creator>Chaudhary, Preeti</creator><creator>Kumar, Rupesh</creator><creator>Verma, Akhilesh K.</creator><creator>Singh, Devender</creator><creator>Yadav, Vibha</creator><creator>Chhillar, Anil K.</creator><creator>Sharma, G.L.</creator><creator>Chandra, Ramesh</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20060315</creationdate><title>Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives</title><author>Chaudhary, Preeti ; Kumar, Rupesh ; Verma, Akhilesh K. ; Singh, Devender ; Yadav, Vibha ; Chhillar, Anil K. ; Sharma, G.L. ; Chandra, Ramesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-628bad97165d73746c643a4e1b7e186eaa78c313983bec1b8bcaa715032750da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal</topic><topic>Antifungal agents</topic><topic>Aspergillus flavus</topic><topic>Aspergillus fumigatus</topic><topic>Aspergillus niger</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cytotoxicity</topic><topic>Erythrocytes - drug effects</topic><topic>Escherichia coli</topic><topic>Fungi - drug effects</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Pharmacology. 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N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds
4d and
6a were found to be very less toxic to human erythrocytes when compared with gentamicin.
A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against
Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),
Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli (MTCCB 1652), and antifungal activity against
Aspergillus fumigatus,
Aspergillus flavus and
Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds
4d and
6a showed very less toxicity against human erythrocytes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16289939</pmid><doi>10.1016/j.bmc.2005.10.032</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2006-03, Vol.14 (6), p.1819-1826 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19952411 |
| source | ScienceDirect Freedom Collection |
| subjects | Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Antifungal agents Aspergillus flavus Aspergillus fumigatus Aspergillus niger Bacteria - drug effects Biological and medical sciences Cytotoxicity Erythrocytes - drug effects Escherichia coli Fungi - drug effects General aspects Humans Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Piperazine Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Pseudomonas aeruginosa Staphylococcus aureus Streptomyces |
| title | Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives |
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