Titanium Implant Materials with Improved Biocompatibility through Coating with Phosphonate-Anchored Cyclic RGD Peptides

One key point for improving osseous integration of implants is to render them osteopromotive by specifically favoring the adhesion of osteoblasts. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix improves cell adhesion in vitro and results in improved and earli...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2005-11, Vol.6 (11), p.2034-2040
Main Authors: Auernheimer, Jörg, Zukowski, Daniel, Dahmen, Claudia, Kantlehner, Martin, Enderle, Anja, Goodman, Simon L, Kessler, Horst
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - metabolism
Inhibitory Concentration 50
integrins
Integrins - antagonists & inhibitors
Materials Testing
Mice
Molecular Structure
Oligopeptides - chemistry
Oligopeptides - pharmacology
Organophosphonates - chemistry
Osteoblasts - metabolism
peptides
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Prostheses and Implants - trends
surface coating
titanium
Titanium - chemistry
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Summary:One key point for improving osseous integration of implants is to render them osteopromotive by specifically favoring the adhesion of osteoblasts. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix improves cell adhesion in vitro and results in improved and earlier osseous integration of implants in vivo. Our approach involves coating titanium implants with a tailor-made cyclic-RGD peptide, thus allowing them to bind to specific integrin receptors on the cell surface through multimeric phosphonates. The advantages of this very stable, new type of anchoring for practical application are presented.
ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200500031