Function of hemopoietic stem cells under conditions of cytostatic myelosuppression and treatment with hemostimilators

We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-11, Vol.140 (5), p.631-634
Main Authors: Zhdanov, V V, Gur'yantseva, L A, Udut, E V, Khrichkova, T Yu, Simanina, E V, Gol'dberg, V E
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Cyclophosphamide - pharmacology
Glucuronic Acid - metabolism
Granulocyte Colony-Stimulating Factor - metabolism
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Hematopoiesis - drug effects
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - physiology
Hematopoietic System - drug effects
Immunosuppressive Agents - pharmacology
Male
Mice
Mice, Inbred CBA
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Summary:We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects of hemostimulators on stem cells are determined by different proportions between proliferation and differentiation processes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0041-3