The possibility of cytochrome P450 1A1/1A2 induction in cells of distant lymph nodes of rats after enteral treatment with benzo[a]pyrene

The mesenteric, mediastinal, and popliteal lymph nodes of rats were studied by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral treatment with benzo[a]pyrene. These cytochrome forms were detected in monocytes, macrophages, reticular and littoral cell...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-11, Vol.140 (5), p.564-567
Main Authors: Borodin, Yu I, Maiborodin, I V, Safina, A F, Strunkin, D N
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Benzo(a)pyrene - administration & dosage
Benzo(a)pyrene - pharmacology
Cytochrome P-450 CYP1A1 - metabolism
Cytochrome P-450 CYP1A2 - metabolism
Endothelium - pathology
Liver - metabolism
Lymph Nodes - drug effects
Lymph Nodes - pathology
Macrophages - metabolism
Male
Monocytes - metabolism
Rats
Rats, Wistar
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Summary:The mesenteric, mediastinal, and popliteal lymph nodes of rats were studied by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral treatment with benzo[a]pyrene. These cytochrome forms were detected in monocytes, macrophages, reticular and littoral cells, cell detritus, and liquid contents of the paracortical and medullary sinuses of all studied lymph nodes. The results indicate that exo- and endogenous toxic substances are oxidized not only in the liver, but also in lymph nodes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0025-3