BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma

Aims:  Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of t(14;18)(q32;q21) and bcl‐2 expression, with a very high percentage of patients surviving more than 5 years. However, cases of t(14;18)(q32;q21)‐positive p...

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Bibliographic Details
Published in:Histopathology 2006-09, Vol.49 (3), p.229-241
Main Authors: Goodlad, J R, Batstone, P J, Hamilton, D A, Kernohan, N M, Levison, D A, White, J M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
BCL2
Biological and medical sciences
Chromosome Aberrations
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 18 - genetics
classification
extranodal
Female
follicular lymphoma
Genes, bcl-2
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Investigative techniques, diagnostic techniques (general aspects)
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Follicular - classification
Lymphoma, Follicular - genetics
Lymphoma, Follicular - mortality
Male
Medical sciences
Middle Aged
Neprilysin - biosynthesis
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
skin
Survival Analysis
Translocation, Genetic
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Summary:Aims:  Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of t(14;18)(q32;q21) and bcl‐2 expression, with a very high percentage of patients surviving more than 5 years. However, cases of t(14;18)(q32;q21)‐positive primary cutaneous FL (PCFL) and examples of t(14;18)(q32;q21)‐negative FL at nodal and other extranodal sites, are well documented. The aim of this study was to test the hypothesis that there is a subtype of FL lacking t(14;18)(q32;q21), which preferentially involves certain sites but is not restricted by anatomical location. Methods and results:  A cohort of 47 stage 1 FL was stratified according to the presence or absence of t(14;18)(q32;q21) using conventional cytogenetics, polymerase chain reaction and interphase fluorescence in situ hybridization. Compared with t(14;18)(q32;q21)‐positive cases, FL lacking the translocation were less likely to express CD10 or bcl‐2 (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2006.02501.x