Late Angiographic Stent Thrombosis After Sirolimus-Eluting Stent Implantation

Background Although drug-eluting stents dramatically reduce revascularization after percutaneous coronary intervention (PCI), it is still unclear whether they increase the risk of stent thrombosis. Late stent thrombosis (>30 days) was a very rare complication after bare metal stent implantation....

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2007, Vol.71(2), pp.226-228
Main Authors: Takahashi, Saeko, Kaneda, Hideaki, Tanaka, Shinji, Miyashita, Yusuke, Shiono, Takaaki, Taketani, Yoshio, Domae, Hiroshi, Matsumi, Junya, Mizuno, Shingo, Minami, Yoshiyasu, Sugitatsu, Kazuya, Saito, Shigeru
Format: Article
Language:English
Subjects:
Aged
Antiplatelet therapy
Blood Vessel Prosthesis Implantation - adverse effects
Coronary Angiography
Coronary Thrombosis - diagnosis
Coronary Thrombosis - etiology
Coronary Thrombosis - prevention & control
Drug-eluting stent
Female
Humans
Immunosuppressive Agents - administration & dosage
Japan
Late stent angiographic thrombosis
Male
Middle Aged
Platelet Aggregation Inhibitors - therapeutic use
Sirolimus - administration & dosage
Sirolimus - adverse effects
Sirolimus-eluting stent
Stents - adverse effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Although drug-eluting stents dramatically reduce revascularization after percutaneous coronary intervention (PCI), it is still unclear whether they increase the risk of stent thrombosis. Late stent thrombosis (>30 days) was a very rare complication after bare metal stent implantation. Four cases of confirmed late angiographic stent thrombosis (LAST) after sirolimus-eluting stent (SES) implantation are presented and the incidence, promoting factors and outcomes of such cases in Japan, where clopidogrel has not been approved, are described. Methods and Results Between September 2004 and March 2006, 725 patients underwent PCI with SES implantation and 679 patients (94%) were clinically followed up (median 271 days). There were 4 cases (0.6%) of LAST (at 60, 180, 215, and 508 days, respectively) after elective SES implantation resulting in myocardial infarction. Three cases occurred soon after antiplatelet therapy discontinuation 3 patients died after LAST events. The incidence of LAST was 0.6%. Conclusions LAST is a rare complication, even after SES implantation, at least in patients with appropriate antiplatelet therapy. However, as it can lead to fatal complications, it must be taken into account, especially when antiplatelet therapy is discontinued. (Circ J 2007; 71: 226 - 228)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.71.226