Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

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Published in:Antimicrobial Agents and Chemotherapy 2007-10, Vol.51 (10), p.3659-3671
Main Authors: Van Voorhis, Wesley C, Rivas, Kasey L, Bendale, Pravin, Nallan, Laxman, Hornéy, Carolyn, Barrett, Lynn K, Bauer, Kevin D, Smart, Brian P, Ankala, Sudha, Hucke, Oliver, Verlinde, Christophe L M J, Chakrabarti, Debopam, Strickland, Corey, Yokoyama, Kohei, Buckner, Frederick S, Hamilton, Andrew D, Williams, David K, Lombardo, Louis J, Floyd, David, Gelb, Michael H
Format: Article
Language:English
Subjects:
Animals
Antimalarials
Antimalarials - chemical synthesis
Antimalarials - pharmacokinetics
Antimalarials - pharmacology
Bile Ducts - metabolism
Caco-2 Cells
Cell Membrane Permeability - drug effects
Crystallography, X-Ray
Dealkylation
Enzyme Inhibitors
Enzyme Inhibitors - pharmacology
Experimental Therapeutics
Farnesyltranstransferase
Farnesyltranstransferase - antagonists & inhibitors
Female
Humans
Malaria - drug therapy
Malaria - parasitology
Male
Mice
Mice, Inbred BALB C
Microsomes, Liver - metabolism
Models, Molecular
Mutagenicity Tests
Parasitic Sensitivity Tests
Plasmodium berghei - drug effects
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - enzymology
Quinolines
Quinolines - chemical synthesis
Quinolines - pharmacokinetics
Quinolines - pharmacology
Rats
Rats, Sprague-Dawley
Sulfonamides
Sulfonamides - chemical synthesis
Sulfonamides - pharmacokinetics
Sulfonamides - pharmacology
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00246-07