DETERMINATION OF GLOMERULAR FILTRATION RATE IN DOGS USING CONTRAST-ENHANCED COMPUTED TOMOGRAPHY

The purpose of this project was to establish a procedure and reference values for glomerular filtration rate (GFR) using contrast‐enhanced computed tomography (CT) in eight healthy dogs. A single section of the kidney was scanned sequentially after bolus injection (3 ml/s) of iohexol (300 mg/kg). Ti...

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Bibliographic Details
Published in:Veterinary radiology & ultrasound 2006-03, Vol.47 (2), p.127-135
Main Authors: O'Dell-Anderson, Kristen J, Twardock, Robert, Grimm, Jennifer B, Grimm, Kurt A, Constable, Peter D
Format: Article
Language:English
Subjects:
Animals
computed tomography
computer software
Contrast Media
diagnostic techniques
Dogs
GFR
glomerular filtration rate
Glomerular Filtration Rate - veterinary
Iohexol
Kidney - diagnostic imaging
Male
normal values
Observer Variation
patlak
Patlak graphical analysis software
Predictive Value of Tests
Radioisotope Renography - veterinary
Reference Values
renal function
Tomography, X-Ray Computed - veterinary
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Summary:The purpose of this project was to establish a procedure and reference values for glomerular filtration rate (GFR) using contrast‐enhanced computed tomography (CT) in eight healthy dogs. A single section of the kidney was scanned sequentially after bolus injection (3 ml/s) of iohexol (300 mg/kg). Time–attenuation curves were constructed and the GFR per volume of kidney was calculated using Patlak graphical analysis software. The GFR was then converted from contrast clearance per unit volume (ml/min/ml) to contrast clearance per body weight (ml/min/kg). Individual kidney and global GFR were calculated using both CT and nuclear scintigraphy. Global GFR for each dog was also determined by plasma iohexol clearance. Contrast‐enhanced CT underestimated the global GFR compared with the other two methods. The average global GFR was 2.57±0.33 ml/min/kg using functional CT and 4.06±0.37 ml/min/kg using plasma iohexol clearance. There was significant (P
ISSN:1058-8183
1740-8261
DOI:10.1111/j.1740-8261.2006.00118.x