Hyperuricemia as a prognostic factor after acute coronary syndrome

Many studies have reported the independent association between uric acid and cardiovascular disease, its role as a risk predictor for outcomes in people with acute coronary syndrome remains controversial. This study aims to assess the association between hyperuricemia and medium/long-term clinical o...

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Bibliographic Details
Published in:Atherosclerosis 2018-02, Vol.269, p.229-235
Main Authors: Lopez-Pineda, Adriana, Cordero, Alberto, Carratala-Munuera, Concepción, Orozco-Beltran, Domingo, Quesada, Jose A., Bertomeu-Gonzalez, Vicente, Gil-Guillen, Vicente F., Bertomeu-Martinez, Vicente
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - therapy
Aged
Aged, 80 and over
Biomarkers - blood
Cardiology
Decision Support Techniques
Female
Humans
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - mortality
Male
Middle Aged
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - mortality
Predictive Value of Tests
Prevalence
Prospective Studies
Registries
Risk Assessment
Risk Factors
Spain - epidemiology
Time Factors
Treatment Outcome
Up-Regulation
Uric acid
Uric Acid - blood
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Summary:Many studies have reported the independent association between uric acid and cardiovascular disease, its role as a risk predictor for outcomes in people with acute coronary syndrome remains controversial. This study aims to assess the association between hyperuricemia and medium/long-term clinical outcomes in people with acute coronary syndrome and determine whether adding hyperuricemia to the GRACE score improves its predictive capability. This cohort study included patients admitted for acute coronary syndrome between 2008 and 2013. Outcomes were cardiovascular and total mortality, and major cardiovascular events. We used a multivariate model to adjust for potential confounding covariates and presented event rates with Kaplan-Meier curves. After adding hyperuricemia to the GRACE score, we compared scores from the reclassification table and the net reclassification improvement. 1119 participants were included and followed-up for a mean of 36 months. Multivariate models showed hyperuricemia was independently associated with higher cardiovascular mortality (HR:1.91; 95% CI:1.32–2.76; p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2018.01.017