Comparison of allergy immunotherapy medication persistence with a sublingual immunotherapy tablet versus subcutaneous immunotherapy in Germany

[...]dosing regimen and frequency of physician's office visits differ considerably between the 2 administration routes, and efficacy and safety profiles of individual products administered through each route vary widely. Because these factors have been reported to affect persistence and adheren...

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Published in:Journal of allergy and clinical immunology 2018-05, Vol.141 (5), p.1898-1901.e5
Main Authors: Allam, Jean-Pierre, Andreasen, Jakob N., Mette, Janina, Serup-Hansen, Niels, Wüstenberg, Eike Gunther
Format: Article
Language:English
Subjects:
Age groups
Allergies
Anticholinergics
Asthma
Clinical trials
Comorbidity
Corticosteroids
Demographics
Family physicians
Immune system
Immunotherapy
Monoclonal antibodies
Oral administration
Patients
Studies
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Summary:[...]dosing regimen and frequency of physician's office visits differ considerably between the 2 administration routes, and efficacy and safety profiles of individual products administered through each route vary widely. Because these factors have been reported to affect persistence and adherence,6 we compared medication persistence and adherence with a SLIT-tablet versus SCIT products in patients with grass pollen allergy over a 3-year period from treatment initiation. The 30-minute waiting time at first intake could be used to provide patients with this information. Because of the retrospective nature of the present study, it was not possible to test this hypothesis. The study period covered the last grass pollen season before the launch of Grazax in Germany in November 2006.IMS Disease Analyzer database The IMS Disease Analyzer database is derived from electronic medical records from a panel of German General Practitioners and other office-based, specialist physicians.E1 It contains information on diagnosis (International Classification of Diseases–Tenth Revision), disease history, prescription medications (including pack size and strength), routine laboratory tests, and referrals. Characteristic SLIT-tablet (n = 2429) SCIT (n = 2109) Mean age (y [SD]) 28.8 (14.8) 26.6 (13.4) Median age (y) 27.0 25.0 Mean age ≥18 y (y [SD]) 35.1 (12.3) 33.1 (11.1) Median age ≥18 (y) 33.0 31.0 Age
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.999