Association of Leptin: Adiponectin ratio and metabolic risk markers in postmenopausal women

• Published in: Immunology letters 2018-04, Vol.196, p.63-67
• Main Authors: Gupta, Vandana, Mishra, Sameeksha, Mishra, Supriya, Kumar, Sandeep, Gupta, Vani
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectin - blood; Biomarkers - blood; Body mass index; Case-Control Studies; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay - methods; Female; Humans; Insulin Resistance; Leptin; Leptin - blood; Lipids - blood; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Middle Aged; Postmenopause - blood; Risk Factors
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2018.01.008

•Metabolic risk factors in postmenopausal women.•Insulin resistance in postmenopausal women with metabolic risk.•Leptin to adiponectin ratio in postmenopausal women with metabolic risk. Leptin and adiponectin play an important role in the regulation of body weight and energy homeostasis. The purpose of the present study was to ascertain the relationship between leptin to adiponectin ratio (L:A) and metabolic risk factors in postmenopausal women.This is a cross sectional case-control study. A total of 523 postmenopausal women were recruited for the study 270 postmenopausal women with metabolic syndrome and 253 apparently healthy control postmenopausal women without metabolic syndrome. Biochemical and Anthropometrical parameters were measured. Leptin and adiponectin levels were determined by sandwich enzyme-linked immunosorbent assay, insulin resistance was determined by homeostasis model assessment for insulin resistance (HOMA-IR). Results of this study indicate that leptin (15.92 ± 10.50 vs.9.43 ± 4.39 pg/ml, p