Acute phase reactant, Pentraxin 3, as a novel marker for the diagnosis of rheumatoid arthritis

Pentraxins are a group of highly conserved acute-phase reactant proteins and play crucial role as modulators of inflammatory processes. Pentraxin 3 (PTX3) is primarily produced and released by vascular cell wall, hence, we attempt to establish the role of PTX3 as a biomarker for Rheumatoid Arthritis...

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Bibliographic Details
Published in:Clinica chimica acta 2018-05, Vol.480, p.65-70
Main Authors: Sharma, A., Khan, R., Gupta, N., Zaheer, M.S., Abbas, M., Khan, S.A.
Format: Article
Language:English
Subjects:
CRP
Diagnostic marker
Pentraxin 3
Rheumatoid arthritis
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Summary:Pentraxins are a group of highly conserved acute-phase reactant proteins and play crucial role as modulators of inflammatory processes. Pentraxin 3 (PTX3) is primarily produced and released by vascular cell wall, hence, we attempt to establish the role of PTX3 as a biomarker for Rheumatoid Arthritis (RA) compared to CRP. Thirty patients having active RA as cases and 30 osteoarthritis (OA) patients as controls were recruited. Paired serum and synovial fluid samples were analysed for concentrations of both PTX3 and CRP by using high sensitivity ELISA kit and ROC curve was plotted. Concentrations of PTX3 and CRP were significantly higher in RA patient serum (p 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2018.01.035