Relationship between postprandial lipemia and atherogenic factors in healthy subjects by considering gender differences

• Published in: Clinica chimica acta 2018-05, Vol.480, p.34-40
• Main Authors: Orem, Asım, Yaman, Serap Ozer, Altinkaynak, Buket, Kural, Birgül Vanizor, Yucesan, Fulya Balaban, Altinkaynak, Yahya, Orem, Cihan
• Format: Article
• Language: English
• Subjects: Area under curve; LDL subfractions; Oral fat tolerance test; Oxidized LDL; Postprandial lipemia
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2018.01.038

Postprandial triglyceride concentrations are clinically significant and independent predictor of cardiovascular disease risk. The purpose of this study was to determine postprandial TG ranges in healthy subjects by considering gender differences. Secondly, assess the relationship between postprandial lipemia and atherogenic indicators. Finally, investigate the use of the postprandial 4h TG test instead of the area under the curve (AUC). Postprandial lipemia was investigated using the standardized oral fat tolerance test (OFTT) in 96 healthy subjects (45 female/51 male). Study group was categorized into tertiles based on AUC calculated using TG concentrations at fasting and 2, 4 and 6h after OFTT. Lipid, lipoproteins, apolipoproteins, LDL subfractions and oxidized LDL (oxLDL) were evaluated in tertiles in both sex groups. The cut-off concentrations for postprandial 4-hour TG concentrations in female and male were 3.20 mmol/L and 4.59 mmol/L, respectively. We observed higher concentrations for atherogenic indicates like small dense-low density lipoprotein (sdLDL), oxLDL values in top tertiles for both groups (P