Association of glycaemic variability evaluated by continuous glucose monitoring with diabetic peripheral neuropathy in type 2 diabetic patients

Purpose Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes, is linked to glycaemic derangements. Glycaemic variability, as a pattern of glycaemic derangements, is a key risk factor for diabetic complications. We investigated the association of glycaemic variability...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2018-05, Vol.60 (2), p.292-300
Main Authors: Hu, Yu-ming, Zhao, Li-hua, Zhang, Xiu-lin, Cai, Hong-li, Huang, Hai-yan, Xu, Feng, Chen, Tong, Wang, Xue-qin, Guo, Ai-song, Li, Jian-an, Su, Jian-bin
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Endocrinology
Glucose
Glucose monitoring
Health risk assessment
Hemoglobin
Humanities and Social Sciences
Internal Medicine
Medicine
Medicine & Public Health
Microvasculature
multidisciplinary
Original Article
Peripheral neuropathy
Science
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes, is linked to glycaemic derangements. Glycaemic variability, as a pattern of glycaemic derangements, is a key risk factor for diabetic complications. We investigated the association of glycaemic variability with DPN in a large-scale sample of type 2 diabetic patients. Methods In this cross-sectional study, we enrolled 982 type 2 diabetic patients who were screened for DPN and monitored by a continuous glucose monitoring (CGM) system between February 2011 and January 2017. Multiple glycaemic variability parameters, including the mean amplitude of glycaemic excursions (MAGE), mean of daily differences (MODD), standard deviation of glucose (SD), and 24-h mean glucose (24-h MG), were calculated from glucose profiles obtained from CGM. Other possible risks for DPN were also examined. Results Of the recruited type 2 diabetic patients, 20.1% ( n  = 197) presented with DPN, and these patients also had a higher MAGE, MODD, SD, and 24-h MG than patients without DPN ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-018-1546-z