Tissue expression of DPP-IV in obesity-diabetes and modulatory effects on peptide regulation of insulin secretion

•DPP-4 activity is increased in hyperglycaemia and insulin resistance.•Enzyme activity, protein and gene expression of DPP-4 are up-regulated in high fat diet-induced obesity in mice.•Tissue distribution patterns of DPP-4 demonstrate highest levels in the small intestine and lungs.•Treatment of HFF...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2018-02, Vol.100, p.165-172
Main Authors: McKillop, Aine M., Stevenson, Claire L., Moran, Brian M., Abdel-Wahab, Yasser H.A., Flatt, Peter R.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - drug effects
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Diet, High-Fat - adverse effects
Dipeptidyl Peptidase 4 - genetics
Dipeptidyl Peptidase 4 - metabolism
Dipeptidyl-Peptidase IV Inhibitors - administration & dosage
Dipeptidyl-peptidase-4 (DPP-4)
Gene Expression Regulation - drug effects
Glucagon-Like Peptide 1 - genetics
Glucagon-Like Peptide 1 - metabolism
Glucose - metabolism
High fat fed
Humans
Hypoglycemic Agents - administration & dosage
Insulin - genetics
Insulin - metabolism
Insulin resistance
Insulin Resistance - genetics
Insulin Secretion - drug effects
Islet
Islets of Langerhans - drug effects
Islets of Langerhans - pathology
Metformin - administration & dosage
Mice
Obesity - drug therapy
Obesity - etiology
Obesity - metabolism
Obesity - pathology
Type 2 diabetes
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Summary:•DPP-4 activity is increased in hyperglycaemia and insulin resistance.•Enzyme activity, protein and gene expression of DPP-4 are up-regulated in high fat diet-induced obesity in mice.•Tissue distribution patterns of DPP-4 demonstrate highest levels in the small intestine and lungs.•Treatment of HFF mice with metformin inhibits DPP-4 activity which may modulate incretin action and control hyperglycaemia. Dipeptidyl peptidase type 4 (DPP-4) inhibitors represent an important class of glucose-lowering drug for type 2 diabetes. DPP-4 enzyme activity has been observed to be significantly altered in type 2 diabetes. Here, the role of DPP-4 was examined in a high fat fed (HFF) mouse model of insulin resistance. HFF mice had an increased bodyweight (p 
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2017.12.020