Sarcopenia in liver transplantation: A review

Summary Background & aims The most recent definition of sarcopenia includes the presence of both low skeletal muscle mass and low skeletal muscle function. As sarcopenia has been associated with numerous poor outcomes in the general surgical population, investigation into its presence in the liv...

Full description

Saved in:
Bibliographic Details
Published in:Clinical nutrition ESPEN 2017-12, Vol.22, p.76-80
Main Authors: Meeks, Anastasia C, Madill, Janet
Format: Article
Language:English
Subjects:
Databases, Factual
Gastroenterology and Hepatology
Humans
Length of Stay
Liver Diseases - epidemiology
Liver Diseases - surgery
Liver Transplantation
Muscle loss
Muscle, Skeletal - metabolism
Sarcopenia
Sarcopenia - diagnosis
Sarcopenia - epidemiology
Sarcopenia - mortality
Tomography, X-Ray Computed
Treatment Outcome
Waiting Lists
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background & aims The most recent definition of sarcopenia includes the presence of both low skeletal muscle mass and low skeletal muscle function. As sarcopenia has been associated with numerous poor outcomes in the general surgical population, investigation into its presence in the liver transplantation population is warranted. This review aims to synthesize the available data regarding sarcopenia and liver transplantation. Methods Data sourcing was completed by searching the following databases: PubMed, Google Scholar and Cochrane. Results Perioperative sarcopenia has been associated with poorer survival, increased wait list mortality and increased length of stay. Although the Model for End-Stage Liver Disease score is routinely used to predict post liver transplantation mortality and morbidity, literature suggests it does not reflect sarcopenic status. Discussion Sarcopenia is associated with poor liver transplantation outcomes. Future research should consider utilizing the recent working definition of sarcopenia and generating diagnostic reference values.
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2017.08.005