Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment

Cancer remains a global health problem and approximately 1.7 million new cancer cases are diagnosed every year worldwide. Although diverse molecules are currently being explored as targets for cancer therapy the tumor treatment and therapy is highly tricky. Secondary messengers are important for hor...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2018-10, Vol.447 (1-2), p.77-92
Main Authors: Kumar, Naveen, Prasad, Peeyush, Jash, Eshna, Saini, Megha, Husain, Amjad, Goldman, Aaron, Sehrawat, Seema
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Brain cancer
Breast cancer
Cancer
Cancer metastasis
Cancer therapies
Cancer treatment
Cardiology
Cell adhesion & migration
Cell migration
Cell Movement
Cell Proliferation
Cyclic adenosine monophosphate
Cyclic AMP
Cyclic AMP - metabolism
Cyclic AMP-Dependent Protein Kinases - metabolism
Cytoskeleton
Global health
Guanine nucleotide exchange factor
Guanine Nucleotide Exchange Factors - metabolism
Humans
Isoforms
Kinases
Life Sciences
Medical Biochemistry
Metabolism
Metastases
Neoplasm Proteins - metabolism
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Oncology
Ovarian cancer
Physiological aspects
Protein kinase A
Protein kinases
Protein turnover
rap GTP-Binding Proteins - metabolism
Rap1 protein
Second Messenger Systems
Signal transduction
Signaling
Telomere-Binding Proteins - metabolism
Therapy
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Summary:Cancer remains a global health problem and approximately 1.7 million new cancer cases are diagnosed every year worldwide. Although diverse molecules are currently being explored as targets for cancer therapy the tumor treatment and therapy is highly tricky. Secondary messengers are important for hormone-mediated signaling pathway. Cyclic AMP (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways. EPAC is also known for its dual role in cancer as pro- and anti-proliferative in addition to metastasis. Results after perturbing EPAC activity suggests its involvement in cancer cell migration, proliferation, and cytoskeleton remodeling which makes it a potential therapeutic target for cancer treatments.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-018-3294-z