Emerging role of the Jun N‐terminal kinase interactome in human health

The c‐Jun N‐terminal kinases (JNKs) are located downstream of Ras‐mitogen activated protein kinase signaling cascades. More than 20 years of study has shown that JNKs control cell fate and many cellular functions. JNKs and their interacting proteins form a complicated network with diverse biological...

Full description

Saved in:
Bibliographic Details
Published in:Cell biology international 2018-07, Vol.42 (7), p.756-768
Main Authors: Guo, Xiao‐Xi, An, Su, Yang, Yang, Liu, Ying, Hao, Qian, Tang, Tao, Xu, Tian‐Rui
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyloid precursor protein
Cell fate
c‐Jun N‐terminal kinases
Insulin
insulin receptor substrate
Insulin resistance
JNK protein
Kinases
MAPK cascade
neurodegenerative disease
Protein kinase
Tumorigenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The c‐Jun N‐terminal kinases (JNKs) are located downstream of Ras‐mitogen activated protein kinase signaling cascades. More than 20 years of study has shown that JNKs control cell fate and many cellular functions. JNKs and their interacting proteins form a complicated network with diverse biological functions and physiological effects. Members of the JNK interactome include Jun, amyloid precursor protein, and insulin receptor substrate. Recent studies have shown that the JNK interactome is involved in tumorigenesis, neuron development, and insulin resistance. In this review, we summarize the features of the JNK interactome and classify its members into three groups: upstream regulators, downstream effectors, and scaffold partners. We also highlight the unique cellular signaling mechanisms of JNKs and provide more insights into the roles of the JNK interactome in human diseases.
ISSN:1065-6995
1095-8355
DOI:10.1002/cbin.10948