Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type

• Published in: Vaccine 2016-07, Vol.34 (33), p.3773-3779
• Main Authors: Sandbulte, Matthew R, Gauger, Phillip C, Kitikoon, Pravina, Chen, Hongjun, Perez, Daniel R, Roth, James A, Vincent, Amy L
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Animal diseases; Animal populations; Animals; antibodies; Antibodies, Viral - blood; Antibody Formation; Antigens; Binding sites; blood serum; cross reaction; Cross Reactions; disease severity; enzyme inhibition; Female; genes; genetic variation; hemagglutinins; Hogs; Human subjects; Immunity, Maternally-Acquired; Immunization; Immunoglobulins; Infections; Influenza A virus; Influenza Vaccines - immunology; lectins; Live attenuated influenza virus; Lungs; Maternally derived antibodies; Mucosal immunity; Mutation; Neuraminidase - immunology; Neuraminidase inhibiting antibodies; Orthomyxoviridae; Orthomyxoviridae Infections - immunology; Pandemics; piglets; respiratory system; Respiratory tract; sialidase; sows; strains; Studies; Swine; Swine Diseases - immunology; Swine Diseases - virology; Swine flu; titration; vaccination; Vaccines; Vaccines, Attenuated - immunology; viral proteins; virus replication; Viruses; Whole inactivated virus
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.06.001

Highlights • The NI responses in pigs vaccinated with LAIV, WIV or WT IAV were measured. • Vaccines induced strong NI responses, but was diminished in the presence of maternal antibodies. • Live viruses administered intranasally also induced NA responses in the respiratory tract. • Viruses containing N2 genes of different genotypes had minimal NA antibody cross-reactivity. • NA components of vaccines for swine must be updated along with the HA.