Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type

Highlights • The NI responses in pigs vaccinated with LAIV, WIV or WT IAV were measured. • Vaccines induced strong NI responses, but was diminished in the presence of maternal antibodies. • Live viruses administered intranasally also induced NA responses in the respiratory tract. • Viruses containin...

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Published in:Vaccine 2016-07, Vol.34 (33), p.3773-3779
Main Authors: Sandbulte, Matthew R, Gauger, Phillip C, Kitikoon, Pravina, Chen, Hongjun, Perez, Daniel R, Roth, James A, Vincent, Amy L
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal diseases
Animal populations
Animals
antibodies
Antibodies, Viral - blood
Antibody Formation
Antigens
Binding sites
blood serum
cross reaction
Cross Reactions
disease severity
enzyme inhibition
Female
genes
genetic variation
hemagglutinins
Hogs
Human subjects
Immunity, Maternally-Acquired
Immunization
Immunoglobulins
Infections
Influenza A virus
Influenza Vaccines - immunology
lectins
Live attenuated influenza virus
Lungs
Maternally derived antibodies
Mucosal immunity
Mutation
Neuraminidase - immunology
Neuraminidase inhibiting antibodies
Orthomyxoviridae
Orthomyxoviridae Infections - immunology
Pandemics
piglets
respiratory system
Respiratory tract
sialidase
sows
strains
Studies
Swine
Swine Diseases - immunology
Swine Diseases - virology
Swine flu
titration
vaccination
Vaccines
Vaccines, Attenuated - immunology
viral proteins
virus replication
Viruses
Whole inactivated virus
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description Highlights • The NI responses in pigs vaccinated with LAIV, WIV or WT IAV were measured. • Vaccines induced strong NI responses, but was diminished in the presence of maternal antibodies. • Live viruses administered intranasally also induced NA responses in the respiratory tract. • Viruses containing N2 genes of different genotypes had minimal NA antibody cross-reactivity. • NA components of vaccines for swine must be updated along with the HA.
doi_str_mv 10.1016/j.vaccine.2016.06.001
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source ScienceDirect Freedom Collection
subjects Allergy and Immunology
Animal diseases
Animal populations
Animals
antibodies
Antibodies, Viral - blood
Antibody Formation
Antigens
Binding sites
blood serum
cross reaction
Cross Reactions
disease severity
enzyme inhibition
Female
genes
genetic variation
hemagglutinins
Hogs
Human subjects
Immunity, Maternally-Acquired
Immunization
Immunoglobulins
Infections
Influenza A virus
Influenza Vaccines - immunology
lectins
Live attenuated influenza virus
Lungs
Maternally derived antibodies
Mucosal immunity
Mutation
Neuraminidase - immunology
Neuraminidase inhibiting antibodies
Orthomyxoviridae
Orthomyxoviridae Infections - immunology
Pandemics
piglets
respiratory system
Respiratory tract
sialidase
sows
strains
Studies
Swine
Swine Diseases - immunology
Swine Diseases - virology
Swine flu
titration
vaccination
Vaccines
Vaccines, Attenuated - immunology
viral proteins
virus replication
Viruses
Whole inactivated virus
title Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type
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