Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp

• Published in: Journal of asian natural products research 2017-07, Vol.19 (7), p.691-696
• Main Authors: Tang, Wei-Zhuo, Yang, Zhong-Zhen, Sun, Fan, Wang, Shu-Ping, Yang, Fan, Lin, Hou-Wen
• Format: Article
• Language: English
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Berries; Cancer; Cytotoxicity; Dichloromethane; Drug Screening Assays, Antitumor; Glycerol; glycerol ether lipid; Glyceryl Ethers - chemistry; Glyceryl Ethers - isolation & purification; Glyceryl Ethers - pharmacology; HeLa Cells; Humans; Imidazole; Imidazole alkaloid; Imidazoles - chemistry; Imidazoles - isolation & purification; Imidazoles - pharmacology; Inhibitory Concentration 50; Leucandra sp; Lipids; Lipids - chemistry; Lipids - isolation & purification; Lipids - pharmacology; Marine Biology; Marine chemistry; MCF-7 Cells; Molecular Structure; neoplasms; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Porifera; Porifera - chemistry; spectral analysis; Tumor cell lines
• ISSN: 1028-6020; 1477-2213; 1477-2213
• DOI: 10.1080/10286020.2016.1240171

Chemical investigation on CH 2 Cl 2 extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC 50 values in the range of 20.1-45.3 μM.