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Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp
Chemical investigation on CH 2 Cl 2 extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literatur...
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| Published in: | Journal of asian natural products research 2017-07, Vol.19 (7), p.691-696 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c427t-5ee39650e14b789e956010499ca0d29fd8c82313603a542571fa37f6995050863 |
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| cites | cdi_FETCH-LOGICAL-c427t-5ee39650e14b789e956010499ca0d29fd8c82313603a542571fa37f6995050863 |
| container_end_page | 696 |
| container_issue | 7 |
| container_start_page | 691 |
| container_title | Journal of asian natural products research |
| container_volume | 19 |
| creator | Tang, Wei-Zhuo Yang, Zhong-Zhen Sun, Fan Wang, Shu-Ping Yang, Fan Lin, Hou-Wen |
| description | Chemical investigation on CH
2
Cl
2
extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC
50
values in the range of 20.1-45.3 μM. |
| doi_str_mv | 10.1080/10286020.2016.1240171 |
| format | article |
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2
Cl
2
extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC
50
values in the range of 20.1-45.3 μM.</description><identifier>ISSN: 1028-6020</identifier><identifier>ISSN: 1477-2213</identifier><identifier>EISSN: 1477-2213</identifier><identifier>DOI: 10.1080/10286020.2016.1240171</identifier><identifier>PMID: 27756152</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Berries ; Cancer ; Cytotoxicity ; Dichloromethane ; Drug Screening Assays, Antitumor ; Glycerol ; glycerol ether lipid ; Glyceryl Ethers - chemistry ; Glyceryl Ethers - isolation & purification ; Glyceryl Ethers - pharmacology ; HeLa Cells ; Humans ; Imidazole ; Imidazole alkaloid ; Imidazoles - chemistry ; Imidazoles - isolation & purification ; Imidazoles - pharmacology ; Inhibitory Concentration 50 ; Leucandra sp ; Lipids ; Lipids - chemistry ; Lipids - isolation & purification ; Lipids - pharmacology ; Marine Biology ; Marine chemistry ; MCF-7 Cells ; Molecular Structure ; neoplasms ; NMR ; Nuclear magnetic resonance ; nuclear magnetic resonance spectroscopy ; Nuclear Magnetic Resonance, Biomolecular ; Porifera ; Porifera - chemistry ; spectral analysis ; Tumor cell lines</subject><ispartof>Journal of asian natural products research, 2017-07, Vol.19 (7), p.691-696</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><rights>2016 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-5ee39650e14b789e956010499ca0d29fd8c82313603a542571fa37f6995050863</citedby><cites>FETCH-LOGICAL-c427t-5ee39650e14b789e956010499ca0d29fd8c82313603a542571fa37f6995050863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27756152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Wei-Zhuo</creatorcontrib><creatorcontrib>Yang, Zhong-Zhen</creatorcontrib><creatorcontrib>Sun, Fan</creatorcontrib><creatorcontrib>Wang, Shu-Ping</creatorcontrib><creatorcontrib>Yang, Fan</creatorcontrib><creatorcontrib>Lin, Hou-Wen</creatorcontrib><title>Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp</title><title>Journal of asian natural products research</title><addtitle>J Asian Nat Prod Res</addtitle><description>Chemical investigation on CH
2
Cl
2
extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC
50
values in the range of 20.1-45.3 μM.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Berries</subject><subject>Cancer</subject><subject>Cytotoxicity</subject><subject>Dichloromethane</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Glycerol</subject><subject>glycerol ether lipid</subject><subject>Glyceryl Ethers - chemistry</subject><subject>Glyceryl Ethers - isolation & purification</subject><subject>Glyceryl Ethers - pharmacology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Imidazole</subject><subject>Imidazole alkaloid</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - isolation & purification</subject><subject>Imidazoles - pharmacology</subject><subject>Inhibitory Concentration 50</subject><subject>Leucandra sp</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Lipids - isolation & purification</subject><subject>Lipids - pharmacology</subject><subject>Marine Biology</subject><subject>Marine chemistry</subject><subject>MCF-7 Cells</subject><subject>Molecular Structure</subject><subject>neoplasms</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Porifera</subject><subject>Porifera - chemistry</subject><subject>spectral analysis</subject><subject>Tumor cell lines</subject><issn>1028-6020</issn><issn>1477-2213</issn><issn>1477-2213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhq0K1O-fALLEhUM3zNhre32jqlo-FIkLPVvurrc4eO1gZ4XCr8dpUg4c4DSe0fO-I89LyCuEBUIH7xBYJ4HBggHKBbIWUOEROcVWqYYx5C_quzLNDjohZ6WsABiiZMfkhCklJAp2SlZLN_c2pujoNbVxoNHaydfu8xV9DNve5RSo23xzmQa_9sMT4yc_2F8pOGrDdxtSHY85TbRidLJ5Jy_rFB8d3bsP2dbBBXk52lDc5aGek_u72683H5vllw-fbq6XTd8ytWmEc1xLAQ7bB9Vpp4UEhFbr3sLA9Dh0fcc4cgncipYJhaPlapRaCxDQSX5O3u591zn9mF3ZmMmX3oVgo0tzMQwAWilQ_R_Fjou201xjRd_8ha7SnGP9iEFdb88FA10psaf6nErJbjTr7OtJtgbB7HIzz7mZXW7mkFvVvT64zw-TG_6onoOqwPs94OOY8mR_phwGs7HbkPKYbex9MfzfO34D3-Sjag</recordid><startdate>20170703</startdate><enddate>20170703</enddate><creator>Tang, Wei-Zhuo</creator><creator>Yang, Zhong-Zhen</creator><creator>Sun, Fan</creator><creator>Wang, Shu-Ping</creator><creator>Yang, Fan</creator><creator>Lin, Hou-Wen</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7SN</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20170703</creationdate><title>Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp</title><author>Tang, Wei-Zhuo ; Yang, Zhong-Zhen ; Sun, Fan ; Wang, Shu-Ping ; Yang, Fan ; Lin, Hou-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-5ee39650e14b789e956010499ca0d29fd8c82313603a542571fa37f6995050863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Berries</topic><topic>Cancer</topic><topic>Cytotoxicity</topic><topic>Dichloromethane</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Glycerol</topic><topic>glycerol ether lipid</topic><topic>Glyceryl Ethers - chemistry</topic><topic>Glyceryl Ethers - isolation & purification</topic><topic>Glyceryl Ethers - pharmacology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Imidazole</topic><topic>Imidazole alkaloid</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - isolation & purification</topic><topic>Imidazoles - pharmacology</topic><topic>Inhibitory Concentration 50</topic><topic>Leucandra sp</topic><topic>Lipids</topic><topic>Lipids - chemistry</topic><topic>Lipids - isolation & purification</topic><topic>Lipids - pharmacology</topic><topic>Marine Biology</topic><topic>Marine chemistry</topic><topic>MCF-7 Cells</topic><topic>Molecular Structure</topic><topic>neoplasms</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Porifera</topic><topic>Porifera - chemistry</topic><topic>spectral analysis</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Wei-Zhuo</creatorcontrib><creatorcontrib>Yang, Zhong-Zhen</creatorcontrib><creatorcontrib>Sun, Fan</creatorcontrib><creatorcontrib>Wang, Shu-Ping</creatorcontrib><creatorcontrib>Yang, Fan</creatorcontrib><creatorcontrib>Lin, Hou-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of asian natural products research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Wei-Zhuo</au><au>Yang, Zhong-Zhen</au><au>Sun, Fan</au><au>Wang, Shu-Ping</au><au>Yang, Fan</au><au>Lin, Hou-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp</atitle><jtitle>Journal of asian natural products research</jtitle><addtitle>J Asian Nat Prod Res</addtitle><date>2017-07-03</date><risdate>2017</risdate><volume>19</volume><issue>7</issue><spage>691</spage><epage>696</epage><pages>691-696</pages><issn>1028-6020</issn><issn>1477-2213</issn><eissn>1477-2213</eissn><abstract>Chemical investigation on CH
2
Cl
2
extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC
50
values in the range of 20.1-45.3 μM.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27756152</pmid><doi>10.1080/10286020.2016.1240171</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1028-6020 |
| ispartof | Journal of asian natural products research, 2017-07, Vol.19 (7), p.691-696 |
| issn | 1028-6020 1477-2213 1477-2213 |
| language | eng |
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| source | Taylor and Francis Science and Technology Collection |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Berries Cancer Cytotoxicity Dichloromethane Drug Screening Assays, Antitumor Glycerol glycerol ether lipid Glyceryl Ethers - chemistry Glyceryl Ethers - isolation & purification Glyceryl Ethers - pharmacology HeLa Cells Humans Imidazole Imidazole alkaloid Imidazoles - chemistry Imidazoles - isolation & purification Imidazoles - pharmacology Inhibitory Concentration 50 Leucandra sp Lipids Lipids - chemistry Lipids - isolation & purification Lipids - pharmacology Marine Biology Marine chemistry MCF-7 Cells Molecular Structure neoplasms NMR Nuclear magnetic resonance nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Porifera Porifera - chemistry spectral analysis Tumor cell lines |
| title | Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp |
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