Development of a novel animal/human hybrid model for multiple sclerosis in SCID-mice with functional human lymphoid system: experimental allergic encephalomyelitis induced by envelope protein from human endogenous retrovirus "W"(MSRV-ENV/Syncytin)

Multiple Sclerosis associated RetroVirus element (MSRV), which further unraveled the HERV-W multicopy family, was discovered to encode a powerful imunopathogenic envelope protein (MSRV-ENV or HERV-W Syncytin copy), causing sequential activation of a pro-inflammatory and autoimmune cascade through in...

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Bibliographic Details
Published in:Journal of neurovirology 2007-01, Vol.13, p.112-112
Main Authors: Perron, H, Sanhadji, K, Popa, I, Bernard, C, Touraine, J-L, Kopp, N, Portoukalian, J
Format: Article
Language:English
Subjects:
Human endogenous retrovirus
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Summary:Multiple Sclerosis associated RetroVirus element (MSRV), which further unraveled the HERV-W multicopy family, was discovered to encode a powerful imunopathogenic envelope protein (MSRV-ENV or HERV-W Syncytin copy), causing sequential activation of a pro-inflammatory and autoimmune cascade through initial interaction with Toll-Like receptor 4 on antigen-presenting cells (APC), accompanied by gliotoxicity causing blood brain barrier (BBB) breakdown and further triggering superantigen-like dysregulation of T-lymphocytes.
ISSN:1355-0284